Results 91 to 100 of about 12,253,362 (313)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

PEASANT INITIATIVE FOR SOIL CONSERVATION: CASE STUDIES OF RECENT TECHNICAL AND SOCIAL INNOVATIONS FROM MAISSADE, HAITI [PDF]

Theories of Haitian underdevelopment, and of the causes and solutions to that underdevelopment are many, complex and often competing. At a very basic level though, Haitian development involves the mastery of ever changing conditions and requires ...
White, Thomas A.
core  

Governance of regional innovations towards sustainability [PDF]

, 2008
This paper addresses the governance of regional innovations towards sustainability. From the literature it is clear that variety is a major source of innovations: innovations come into being in interplay between a variety of public and private actors who
Termeer, C.J.A.M., Kranendonk, R.P.
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Fostering Community Ownership for Sustainable Social Innovations in Pastoral and Agro-Pastoral Regions

Challenges
Social innovation has emerged as a prominent strategy in development practice, attracting substantial scholarly attention. In Ethiopia’s pastoral and agro-pastoral areas, characterized by vulnerability and persistent development challenges, non ...
Mulye Tadesse, Tafesse Matewos, Samuel Jilo Dira, Fekadu Israel Alambo, Tenaw Fentaw Dessie   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The role of external involvement in the creation of management innovations [PDF]

, 2014
There has recently been renewed scholarly interest in management innovating, the creation of new organizational practices, structures, processes and techniques. We suggest that external involvement in the process of management innovating can transpire in
Michael J. Mol, Mol, Michael J., Birkinshaw, J., Birkinshaw, J, Julian Birkinshaw, Mol, M, Birkinshaw, Julian, Mol, Machiel   +7 more
core   +1 more source

Correction: Advancing behavioral interventions for African American/Black and Latino persons living with HIV using a new conceptual model that integrates critical race theory, harm reduction, and self-determination theory: a qualitative exploratory study

International Journal for Equity in Health, 2022
Marya Gwadz, Sabrina R. Cluesman, Robert Freeman, Linda M. Collins, Caroline Dorsen, Robert L. Hawkins, Charles M. Cleland, Leo Wilton, Amanda S. Ritchie, Karen Torbjornsen, Noelle R. Leonard, Belkis Y. Martinez, Elizabeth Silverman, Khadija Israel, Alexandra Kutnick   +14 more
doaj   +1 more source

Knowledge Triangle Configurations at Three Swedish Universities

Foresight and STI Governance, 2017
The concept of a knowledge triangle, i.e., the principle of strengthening the linkages between research, education and innovation, has emerged as a result of policymakers’ expectations that universities to assume broader social responsibility.
Perez-Vico Eugenia, Sylvia Schwaag Serger, Emily Wise, Mats Benner   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source