Results 101 to 110 of about 12,253,362 (313)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Indirect social influence and diffusion of innovations: An experimental approach [PDF]

open access: yes
A fundamental feature for understanding the diffusion of innovations through a social group is the manner in which we are influenced by our own social interactions.
Pereda García, María   +3 more
core   +1 more source

The role of stakeholders in social innovations

open access: yesSocial Entrepreneurship Review, 2019
In the modern world, the role and importance of social innovations as solutions to existing social or sustainable development challenges is growing. Research suggest that it is not possible to design and implement social innovation effectively without ...
Daria Murawska
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

open access: yesMolecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara   +10 more
wiley   +1 more source

Social innovations in Croatia

open access: yes, 2019
Socijalne inovacije su kreativni odgovor na nove i drugačije društvene probleme. Najistaknutije su organizacije civilnog društva zbog fokusa na građane i lokalne okolnosti, iako se socijalne inovacije pojavljuju i u drugim sektorima.
Šuflaj, Lidija
core  

Mobile technologies as support for social innovations

open access: yesSocial Entrepreneurship Review, 2019
Social innovation is an integral part of innovation policy. It can effectively address social needs as well as create new value for every society. Today, mobile technologies become an increasingly important component in leveraging innovation and thus ...
Weronika Kotyza, Anna Stronczek
doaj   +1 more source

The role of digital social innovations to address SDGs: A systematic review. [PDF]

open access: yesEnviron Dev Sustain, 2023
Dionisio M   +3 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

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