Results 51 to 60 of about 1,062,305 (293)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Urban Planning, 2022 Renderings are digital visualisations of urban development projects in the field of urban design that aim to create spatial knowledge about future-built urban environments, which we also refer to as imaginaries.
Sophie Mélix, Gabriela Christmann
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
THE FORMATION OF INNOVATION COMPETENCE OF FUTURE SOCIAL SPHERE SPECIALIST
Вестник Тамбовского университета. Серия: Гуманитарные науки, 2017 The transformations, occurring in the social sphere of Russia are analyzed. At the modern stage the transition from stagnancy in the social sphere to the development, this period is characterized by the implementation of innovative technologies of social
A. A. Druzhinina
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
BMC Geriatrics, 2019 Background If technologies are to support aging in place, then it is important to develop fundamental knowledge on what causes stability and changes in the use of technologies by seniors. However, longitudinal studies on the long-term use of technologies
S. T. M. Peek +7 more
doaj +1 more source
A Need for Co-Evolution between Technological Innovations and Social Innovations
Journal of Open Innovation: Technology, Market and Complexity, 2020 The 4th industrial revolution must be approached from the perspective of industrial ecosystem in order to lead to industrial reorganization facing after deindustrialization. This is because, as the characteristics of agriculture and manufacturing differ,
Pae Kun Choi
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Institutional Innovation in New Towns: The Dual Developer Concept [PDF]
, 1975 New communities have long been celebrated as models for increased order and quality in the process by which rural land is brought into urban use and urban land into more intensive use. At the community level, innovations may be more readily tested in new
Nicoson, William
core +1 more source