Results 101 to 110 of about 870,885 (308)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Current learning strategies in fire evacuation for seniors and people with disabilities in private seniors’ residences and long-term care homes: a scoping review

Frontiers in Rehabilitation Sciences
Current strategies for teaching evacuation methods in private seniors’ residences (PSR) and long-term care (LTCH) homes may pose risks to people with disabilities (PWD) and seniors' physical and psychological health.
William Thériault, William Thériault, Guillaume Blanchet, Guillaume Blanchet, Claude Vincent, Claude Vincent, Isabelle Feillou, Isabelle Feillou, Jean Ruel, Jean Ruel, Ernesto Morales, Ernesto Morales   +11 more
doaj   +1 more source

Institute on Community Integration Annual Report: 2007-08

, 2008
The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Center for Excellence in Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Institute on Community Integration Annual Report: 1999-00

, 2000
The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Affiliated Program on Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Institute on Community Integration Annual Report: 1992-93

, 1993
The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Affiliated Program on Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Could a feedback device help manage work-related shoulder disorders?: protocol of a mixed methods pilot study

Pilot and Feasibility Studies
Background Work-related shoulder disorders (WRSDs) significantly impact workers’ health and well-being. Various factors contribute to WRSDs, including work environment, physical workload, psychological stressors, and an aging workforce.
Philippe Meidinger, Quan Nha Hong, Jean Tittley, Alexandre Campeau-Lecours, Jean-Sébastien Roy   +4 more
doaj   +1 more source

Institute on Community Integration Annual Report: 2001-02

, 2002
The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Center for Excellence in Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
core