Results 121 to 130 of about 13,585,894 (350)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Poverty and social integration in the enlarged Europe [PDF]

Empirical studies of the old EU countries suggest that poverty brings limited social relations and a lack of social support in its wake. At the same time, it is thought that in the transition countries, especially, individual supply crises are ...
Böhnke, Petra
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Adaptive service discovery on service-oriented and spontaneous sensor systems [PDF]

, 2012
Service-oriented architecture, Spontaneous networks, Self-organisation, Self-configuration, Sensor systems, Social patternsNatural and man-made disasters can significantly impact both people and environments.
Antonopoulos, Nikolaos, Li, Jianxin, Liu, Lu, Wu, Kaigu, Xu, Jie   +4 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Could a feedback device help manage work-related shoulder disorders?: protocol of a mixed methods pilot study

Pilot and Feasibility Studies
Background Work-related shoulder disorders (WRSDs) significantly impact workers’ health and well-being. Various factors contribute to WRSDs, including work environment, physical workload, psychological stressors, and an aging workforce.
Philippe Meidinger, Quan Nha Hong, Jean Tittley, Alexandre Campeau-Lecours, Jean-Sébastien Roy   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Altering visual feedback during reaching: no mitigating effect on pain for individuals with complex regional pain syndrome, but visuomotor adaptation is preserved

Frontiers in Human Neuroscience
IntroductionComplex regional pain syndrome (CRPS) is often associated with pain-related fear of movement, and virtual reality has been proposed as a potential rehabilitation intervention to overcome this issue. Therefore, this cross-sectional study aimed
Marion Dagenais, Marion Dagenais, Chloé Sutter, Chloé Sutter, Clémentine Brun, Clémentine Brun, Anne Marie Pinard, Anne Marie Pinard, Anne Marie Pinard, Jean-Sébastien Roy, Jean-Sébastien Roy, Catherine Mercier, Catherine Mercier   +12 more
doaj   +1 more source

Housing First and Social Integration: A Realistic Aim?

, 2016
Housing First is now dominating discussions about how best to respond to homelessness among people with high and complex needs throughout the EU and in several countries within the OECD.
D. Quilgars, N. Pleace
semanticscholar   +1 more source