Results 131 to 140 of about 1,524,576 (347)

Factors affecting social isolation among the young adults in South Korea: A cross-sectional analysis [PDF]

, 2022
Soo‐Bi Lee, Yerim Shin, Yebin Jeon, Seohyun Kim   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Telerehabilitation program maintains functional capacity in patients with chronic lung disease during a period of social isolation owing to covid-19 (Preprint)

, 2022
Aline Paula Miozzo, Natiele Camponogara Righi, Maria Luiza Yumi Shizukuishi, Hérica Ferreira Marques, Juliessa Florian, Scheila da Costa Machado, Jociane Schardong, Rodrigo Della Méa Plentz   +7 more
openalex   +1 more source

Social Isolation, Hospitalization, and Deaths from Cardiovascular Diseases during the COVID-19 Epidemic in São Paulo Metropolitan Area in 2020 [PDF]

, 2022
Lucas Rodrigues de Lima, Paulo Francisco Auricchio da Ponte, Lucca Novais Dias, Marcelo Henrique Lima Silvestre, Paulo Suen, Antônio de Pádua Mansur   +5 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Is self-regulation a burden or a virtue? A comparative perspective [PDF]

, 2014
Confucianism demands that individuals comport themselves according to the strictures of ritual propriety—specific forms of speech, clothing, and demeanor attached to a vast array of life circumstances.
Sarkissian, Hagop
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Latent profiles and transitions of social isolation among older adults and their influencing factors: a person-centered approach

Frontiers in Public Health
IntroductionIn the context of global aging, it is crucial to understand the heterogeneity, changing trends, and influencing factors of social isolation in older people.Methods7198 older people over 60 in China Longitudinal Aging Social Survey in 2016 and
Xuezhi Liu, Xuezhi Liu, Yanzhen Zhang, Jianxiao Wu, Yadi Zeng, Lingjing Guo, Baojuan Ye   +6 more
doaj   +1 more source

Reentry During A Pandemic: A Pilot Study of Access to Peer Support Through Technology to Reduce Social Isolation [PDF]

, 2022
Stacy C. Moak, Lindsay Leban, Tina Kempin Reuter   +2 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source