Results 111 to 120 of about 431,994 (303)

The association between mental status, personality traits, and discrepancy in social isolation and perceived loneliness among community dwellers

BMC Public Health
Background Social isolation and loneliness can co-occur; however, they are distinct concepts. There is discrepancy as some people feel lonely in social isolation, while others do not.
Kumi Watanabe Miura, Takuya Sekiguchi, Mihoko Otake-Matsuura   +2 more
doaj   +1 more source

Combating social isolation in older adults

, 2020
Purpose: The purpose of this research project is to explore social isolation in older adults and the ways the Veterans Home of California, a skilled residential nursing facility, promotes social connectedness for its residents.
Garbaccio, Gina
core  

Impact of social isolation on mortality and morbidity in 20 high-income, middle-income and low-income countries in five continents

, 2021
DigitalObjective To examine the association between social isolation and mortality and incident diseases in middle-aged adults in urban and rural communities from high-income, middle-income and low-income countries.
Seron, Pamela, Khatib, Rasha, Naito, Ryo, Avezum, Alvaro, Gupta, Rajeev, Bangdiwala, Shrikant Ishver, McKee, Martin, Kaur, Manmeet, Karsidag, Kubilay, Dans, Antonio L., Puoane, Thandi, Teo, Koon, Islam, Shofiqul, Yusuf, Salim, Zhu, Yibing, Yusufali, Afzalhussein, Alhabib, Khalid F., Lopez-Jaramillo, Patricio, Diaz, Rafael, Rahman, Omar, Liu, Weida, Rosengren, Annika, Lear, Scott A., Szuba, Andrzej, Yeates, Karen, K. R., Leela Itty Amma, Rosnah, Ismail, Rangarajan, Sumathy, Chifamba, Jephat, Subramanian, S. V., Sheng, Yundong, Iqbal Azam, Syed, Kelishadi, Roya, Leong, Darryl P.   +33 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Age-related impact of social isolation in mice: Young vs middle-aged

Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as well as spatial memory impairments, in middle-aged ...
Sebastião, Ana M, Valente, Cláudia A, Mampay, Myrthe, Sheridan, Graham K., Sheridan, Graham K, Magalhães, Daniela M, Valente, Cláudia A.   +6 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effects of Post-Weaning Social Isolation and Oxytocin on Adult Anxiety and Sociability in Female Rats

, 2018
Positive social interactions during childhood and adolescence are essential for human neurobehavioral development. All social animals show persistent physiological and behavioral deficits after extended periods of social isolation.
Hassan H. López, Flip Phillips, Ryan Toma, Morgan Lavoie   +3 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Loneliness and Social Isolation [PDF]

, 2006
de Jong Gierveld, J., van Tilburg, T.G., Dykstra, P.A.   +2 more
openaire   +5 more sources

Peri-adolescence isolation rearing alters social behavior and nociception in rats

, 2010
Social isolation results in fundamental behavioral abnormalities in rodents which models certain neuropsychiatric disorders such as schizophrenia. However, the developmental stage that is most vulnerable to social isolation is largely unknown.
Meng, Qingxuan, Wang, Weiwen, Shao, Feng, 王玮文, Han, Xiao, Feng Shao, Li, Nanxin   +6 more
core