Results 101 to 110 of about 431,994 (303)

How to be a resilient researcher of social isolation

, 2014
Project Insight for Native Magazine: I am going to be reflexive on the promises of our project, which is to reduce social isolation by engaging an audience aged 65 and above.
Windle, Amanda
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Loneliness, social isolation and psychiatric disorders: insights from the National Mental Health Survey in Korea

BJPsych Open
Background Loneliness and social isolation pose significant public health concerns globally, with adverse effects on mental health and well-being. Although the terms are often used interchangeably, loneliness refers to the subjective feeling of lacking
Eun Jung Kim, Ji Hyun An, Jin Young Jung, Bong Jin Hahm, Jin Pyo Hong   +4 more
doaj   +1 more source

Enforced versus Voluntary Social Isolation and User’s Interaction with Online News

, 2022
COVID-19 has caused severe damage to all nations across the world. Some governments enforced strict regional or nationwide lockdowns to control the spread of the virus. Other factors such as infodemic have also affected individuals.
Khobzi, Hamid
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Concept analysis of social isolation among the elderly in nursing homes

Huli yanjiu
ObjectiveTo explore the definition and connotative characteristics of the concept of social isolation among the elderly in nursing homes.MethodsThe system retrieved relevant literature on social isolation among the elderly from databases such as PubMed ...
LI Weitong, LI Yilin
doaj  

The relationship between social isolation and cognitive function in older patients with chronic obstructive pulmonary disease: a latent profile analysis

BMC Geriatrics
Background To explore the potential classes of social isolation in older patients with chronic obstructive pulmonary disease (COPD), analyze the influencing factors of these classes, and investigate the relationship between different classes and ...
Minghua Han, Hongxia Wu, Huize Xu, Jian Zhao, Zhongwen Chang, Qian Zhao   +5 more
doaj   +1 more source

Principals' Perceptions of Isolation and Contributing Factors: A Mixed Methods Analysis [PDF]

Principals’ perceived isolation has been empirically associated with factors such as lower self-efficacy, job dissatisfaction, and burnout and a strong predictor of a principal's intentions to leave the profession.
Glaze, James
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source