Results 101 to 110 of about 12,603,881 (290)
Social Isolation and Depression among Elderly from an Indian Urban Slum Population
Journal of the Indian Academy of GeriatricsBackground: The aim of the study was to understand the reported prevalence of subjective, objective social isolation, marginal family, and marginal friendship ties in relation to each other.
Mohan Kumar, Manisha Ruikar, V. L. Surya
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Concept analysis of social isolation among the elderly in nursing homes
Huli yanjiuObjectiveTo explore the definition and connotative characteristics of the concept of social isolation among the elderly in nursing homes.MethodsThe system retrieved relevant literature on social isolation among the elderly from databases such as PubMed ...
LI Weitong, LI Yilin
doaj
BMC GeriatricsBackground To explore the potential classes of social isolation in older patients with chronic obstructive pulmonary disease (COPD), analyze the influencing factors of these classes, and investigate the relationship between different classes and ...
Minghua Han +5 more
doaj +1 more source
BJPsych OpenBackground Loneliness and social isolation pose significant public health concerns globally, with adverse effects on mental health and well-being. Although the terms are often used interchangeably, loneliness refers to the subjective feeling of lacking
Eun Jung Kim +4 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Age-related impact of social isolation in mice: Young vs middle-aged [PDF]
Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as well as spatial memory impairments, in middle-aged ...
Sebastião, Ana M +6 more
core +1 more source
Combating social isolation in older adults [PDF]
, 2020 Purpose: The purpose of this research project is to explore social isolation in older adults and the ways the Veterans Home of California, a skilled residential nursing facility, promotes social connectedness for its residents.
Garbaccio, Gina
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source