Results 91 to 100 of about 12,603,881 (290)

Neighborhood social cohesion and physical disorder in relation to social isolation in older adults: racial and ethnic differences

BMC Public Health
Background Neighborhood factors of social isolation have been understudied, hindering efforts to reduce social isolation at the neighborhood level. This study aims to investigate the longitudinal effects of neighborhood social cohesion and physical ...
Weidi Qin, Emily J. Nicklett, Jiao Yu, Ann W. Nguyen   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The role of social influence, charismatic leadership, and social isolation in predicting cult affiliation intentions among Malaysian youth [PDF]

This study examines the roles of perceived social influence, charismatic leadership, and social isolation in predicting cult affiliation intentions among Malaysian youth.
Abdullah, Haslinda, H. Hamsan, Hanina, Ma’rof, Aini Azeqa   +2 more
core   +1 more source

Using machine learning to understand social isolation and loneliness in schizophrenia, bipolar disorder, and the community

Schizophrenia
Social disconnection, including objective social isolation and subjective loneliness, is linked to substantial health risks. Yet, little is known about the predictors of social disconnection in individuals with mental illness.
Samuel J. Abplanalp, Michael F. Green, Jonathan K. Wynn, Naomi I. Eisenberger, William P. Horan, Junghee Lee, Amanda McCleery, David J. Miklowitz, L. Felice Reddy, Eric A. Reavis   +9 more
doaj   +1 more source

“I Am Actually Scared of Everyone”: Older Adults’ Experiences of Social Isolation during COVID-19: A Qualitative Systematic Review

COVID
The emergence of the coronavirus COVID-19 in December 2019 in Wuhan, China, affected all facets of people’s lives worldwide. As a result of the severity of the pandemic, governments worldwide adopted several policies and containment measures, such as ...
Oladapo Akinlotan, Aishatu Jalo
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Waste Isolation Pilot Plant 1999 Site Environmental Report [PDF]

, 2000
The U.S. Department of Energy s (DOE)Carlsbad Area Office and the Westinghouse Waste Isolation Division (WID) are dedicated to maintaining high quality management of Waste Isolation Pilot Plant (WIPP) environmental resources.
Division, Westinghouse Waste Isolation, Warren, Ronald W., Luft, Amy Adams, Evans, Roy B., Martin, Don, Reynolds, Timothy D., Morris, Randall C.   +6 more
core   +1 more source

Correlates Of Resilience In The Context Of Social Isolation In Seniors (CRISIS)

, 2021
CRISIS - Correlates of Resilience in the Context of Social Isolation in ...
Hoffmann, Martine, MURDOCK, Elke, ALBERT, Isabelle, Nell, Josepha, KORNADT, Anna Elena   +4 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source