Results 21 to 30 of about 346,144 (257)

Parent Quality of Life at Two Years Following Their Child's Completion of Acute Lymphoblastic Leukemia Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra, Maria McCarthy, Michael Takagi, Cinzia De Luca   +3 more
wiley   +1 more source

Social isolation among adolescents and its association with depression symptoms

Middle East Current Psychiatry, 2023
Background Social isolation can be defined as the absence of social interactions, contacts, and relationships with family, friends, and neighbors. According to some studies, social isolation was associated with depressive symptoms.
Danah A. Alsadoun, Haneen S. Alotaibi, Amwaj I. Alanazi, Leena A. Almohsen, Njoud N. Almarhoum, Samira Mahboub   +5 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Social isolation in older adults with type 2 diabetes mellitus—a path analysis

Frontiers in Public Health
BackgroundDue to aging, the use of antidiabetic drugs, and dietary restrictions following a diagnosis of type 2 diabetes mellitus (T2DM), the social interactions of older adults with T2DM are often limited.
Jing Wang, Xiaoyan Bai, Keke Lin, Chao Sun, Quanying Wu, Ruiting Zhang, Yu Liu   +6 more
doaj   +1 more source

Poststress social isolation exerts anxiolytic effects by activating the ventral dentate gyrus

Neurobiology of Stress, 2023
After aversive stress, people either choose to return to their previously familiar social environment or tend to adopt temporary social withdrawal to buffer negative emotions.
Huiyang Lei, Huaqing Shu, Rui Xiong, Ting He, Jingru Lv, Jiale Liu, Guilin Pi, Dan Ke, Qun Wang, Xifei Yang, Jian-Zhi Wang, Ying Yang   +11 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The effects of social isolation on well-being and life satisfaction during pandemic

Humanities & Social Sciences Communications, 2021
The SARS-CoV-2 pandemic placed many locations under ‘stay at home” orders and adults simultaneously underwent a form of social isolation that is unprecedented in the modern world.
Ruta Clair, Maya Gordon, Matthew Kroon, Carolyn Reilly   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Differentiating objective and subjective dimensions of social isolation and apprasing their relations with physical and mental health in italian older adults

BMC Geriatrics, 2020
Background International research shows that social isolation is harmful for health, especially for the elderly. Its objective and subjective dimensions are important to distinguish as each stands in a different relation with health. The first aim of the
Maddalena Fiordelli, Gabriele Sak, Benedetta Guggiari, Peter J. Schulz, Serena Petrocchi   +4 more
doaj   +1 more source