Results 41 to 50 of about 429,951 (303)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Social isolation in older adults with type 2 diabetes mellitus—a path analysis

Frontiers in Public Health
BackgroundDue to aging, the use of antidiabetic drugs, and dietary restrictions following a diagnosis of type 2 diabetes mellitus (T2DM), the social interactions of older adults with T2DM are often limited.
Jing Wang, Xiaoyan Bai, Keke Lin, Chao Sun, Quanying Wu, Ruiting Zhang, Yu Liu   +6 more
doaj   +1 more source

The effects of social isolation on well-being and life satisfaction during pandemic

Humanities & Social Sciences Communications, 2021
The SARS-CoV-2 pandemic placed many locations under ‘stay at home” orders and adults simultaneously underwent a form of social isolation that is unprecedented in the modern world.
Ruta Clair, Maya Gordon, Matthew Kroon, Carolyn Reilly   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Differentiating objective and subjective dimensions of social isolation and apprasing their relations with physical and mental health in italian older adults

BMC Geriatrics, 2020
Background International research shows that social isolation is harmful for health, especially for the elderly. Its objective and subjective dimensions are important to distinguish as each stands in a different relation with health. The first aim of the
Maddalena Fiordelli, Gabriele Sak, Benedetta Guggiari, Peter J. Schulz, Serena Petrocchi   +4 more
doaj   +1 more source

Advancing loneliness and social isolation as global health challenges: taking three priority actions

Public Health Research & Practice, 2023
Loneliness and social isolation have been identified as critical global health issues in the aftermath of the coronavirus disease 2019 (COVID-19) crisis.
Michelle H Lim , Pamela Qualter, Ding Ding, Julianne Holt-Lunstad, Christopher Mikton, Ben J Smith   +5 more
doaj   +1 more source

Rate of Social Isolation by Geographic Location Among Older Adults: AAA LongROAD Study

Frontiers in Public Health, 2021
Introduction: Social isolation is a modifiable risk factor for negative health outcomes among older adults. This work assessed the relationship between geography (i.e., urban vs.
Laura Lynch, Thelma J. Mielenz, Guohua Li, Guohua Li, David W. Eby, Lisa J. Molnar, Marian E. Betz, Carolyn DiGuiseppi, Linda L. Hill, Vanya Jones, David Strogatz   +10 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source