Results 51 to 60 of about 362,272 (255)

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

An observational analysis of frailty in combination with loneliness or social isolation and their association with socioeconomic deprivation, hospitalisation and mortality among UK Biobank participants

Scientific Reports
Frailty, social isolation, and loneliness have individually been associated with adverse health outcomes. This study examines how frailty in combination with loneliness or social isolation is associated with socioeconomic deprivation and with all-cause ...
Marina Politis, Lynsay Crawford, Bhautesh D. Jani, Barbara I. Nicholl, Jim Lewsey, David A. McAllister, Frances S. Mair, Peter Hanlon   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Juvenile social isolation in Sprague Dawley rats does not have a lasting impact on social behavior in adulthood

Scientific Reports
Adolescent social interactions are essential for shaping adult behavior in humans. While rodent studies have highlighted the impact of social isolation on behavior, many extend isolation into adulthood, making it challenging to pinpoint the long-term ...
Michelle Kim, Shai Netser, Shlomo Wagner, Hala Harony-Nicolas   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effects of short-term isolation on social behaviors in prairie voles.

PLoS ONE
Social isolation affects the brain and behavior in a variety of animals, including humans. Studies in traditional laboratory rodents, including mice and rats, have supported the idea that short-term social isolation promotes affiliative social behaviors,
Jesus E Madrid, Nicole M Pranic, Samantha Chu, Johanna J D Bergstrom, Rhea Singh, Joclin Rabinovich, Kaycee Arias Lopez, Alexander G Ophir, Katherine A Tschida   +8 more
doaj   +1 more source

Perceived Social Isolation and Outcomes in Patients With Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundPerceived social isolation has been shown to have a negative impact on health outcomes, particularly among older adults. However, these relationships have not been fully examined among patients with heart failure.
Sheila M. Manemann, Alanna M. Chamberlain, Véronique L. Roger, Joan M. Griffin, Cynthia M. Boyd, Thomas K. M. Cudjoe, Daniel Jensen, Susan A. Weston, Matteo Fabbri, Ruoxiang Jiang, Lila J. Finney Rutten   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Post-weaning social isolation alters sociability in a sex-specific manner

Frontiers in Behavioral Neuroscience
Adolescence is a critical period for brain development in humans and stress exposure during this time can have lasting effects on behavior and brain development.
Teneisha Myers, Elizabeth A. Birmingham, Brigham T. Rhoads, Anna G. McGrath, Nylah A. Miles, Carmen B. Schuldt, Lisa A. Briand, Lisa A. Briand   +7 more
doaj   +1 more source