Results 51 to 60 of about 12,603,881 (290)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Social Isolation and Inequality [PDF]

There is an increasing interest in the concept of social exclusion and the related concept of social isolation and their potential role in understanding inequality.
Dan Silverman, Andrew Postlewaite
core   +2 more sources

Association between internet use and social isolation among nursing home residents: a chain mediation model

BMC Geriatrics
Background Social isolation poses a significant threat to the health of older adults. However, there has been a lack of attention to the relationship between Internet use and social isolation.
Qiyuan Huang, Huangqin Liu, Wan Cheng, Sheng Wu, Song Ge, Yuanfeng Lu, Jinyi Wu, Bingqian Ou, Huimin Xiao   +8 more
doaj   +1 more source

Differentiating objective and subjective dimensions of social isolation and apprasing their relations with physical and mental health in italian older adults

BMC Geriatrics, 2020
Background International research shows that social isolation is harmful for health, especially for the elderly. Its objective and subjective dimensions are important to distinguish as each stands in a different relation with health. The first aim of the
Maddalena Fiordelli, Gabriele Sak, Benedetta Guggiari, Peter J. Schulz, Serena Petrocchi   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The Heterogeneity of Socially Isolated Older Adults: A Social Isolation Typology

Journal of Gerontological Social Work, 2015
Recent statistics show a growing number of older adults who are living alone and are socially isolated. It is against this background that, in recent years, many interventions have been developed to address social isolation among the elderly. Evaluative studies show that most interventions are hardly effective, though.
openaire   +4 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The associations of social isolation with depression and anxiety among adults aged 65 years and older in Ningbo, China

Scientific Reports
Social isolation was associated with emotional problems (depression and anxiety) among older adults, however, little is known in China. Thus, we conducted a cross-sectional study including 6,664 ≥ 65 years older adults in Ningbo, China. We collected data
Lian Li, Kaijie Pan, Jincheng Li, Meiqin Jiang, Yan Gao, Hongying Yang, Guolin Bian   +6 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Social isolation and loneliness in old age: Exploring their role in mental and physical health

, 2021
The current review has the ultimate scope to accurately define social isolation and loneliness while highlighting the serious repercussions on health and behavior.
Giannouli, V., Tragantzopoulou, G.
core   +1 more source