Results 61 to 70 of about 431,994 (303)

Recovery from social isolation requires dopamine in males, but not the autism-related gene nlg3 in either sex

Royal Society Open Science
Social isolation causes profound changes in social behaviour in a variety of species. However, the genetic and molecular mechanisms modulating behavioural responses to social isolation and social recovery remain to be elucidated.
Ryley T. Yost, Andrew M. Scott, Judy M. Kurbaj, Brendan Walshe-Roussel, Reuven Dukas, Anne F. Simon   +5 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The experience of social isolation among community-dwelling older adults: a qualitative study

BMC Geriatrics
Background Social isolation is a major problem for older adults. Increasing evidence suggests that perceived social isolation is linked to adverse physical and mental health outcomes among older adults.
Mengfan He, Shitong Guo, Xiang Sun, Yi Yu, Ling Li, Jinhua Zhang, Shiguang Wang, Shuya Li, Peng Wang, Lin Zhang   +9 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An observational analysis of frailty in combination with loneliness or social isolation and their association with socioeconomic deprivation, hospitalisation and mortality among UK Biobank participants

Scientific Reports
Frailty, social isolation, and loneliness have individually been associated with adverse health outcomes. This study examines how frailty in combination with loneliness or social isolation is associated with socioeconomic deprivation and with all-cause ...
Marina Politis, Lynsay Crawford, Bhautesh D. Jani, Barbara I. Nicholl, Jim Lewsey, David A. McAllister, Frances S. Mair, Peter Hanlon   +7 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Juvenile social isolation in Sprague Dawley rats does not have a lasting impact on social behavior in adulthood

Scientific Reports
Adolescent social interactions are essential for shaping adult behavior in humans. While rodent studies have highlighted the impact of social isolation on behavior, many extend isolation into adulthood, making it challenging to pinpoint the long-term ...
Michelle Kim, Shai Netser, Shlomo Wagner, Hala Harony-Nicolas   +3 more
doaj   +1 more source

Post-weaning social isolation alters sociability in a sex-specific manner

Frontiers in Behavioral Neuroscience
Adolescence is a critical period for brain development in humans and stress exposure during this time can have lasting effects on behavior and brain development.
Teneisha Myers, Elizabeth A. Birmingham, Brigham T. Rhoads, Anna G. McGrath, Nylah A. Miles, Carmen B. Schuldt, Lisa A. Briand, Lisa A. Briand   +7 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Effects of short-term isolation on social behaviors in prairie voles.

PLoS ONE
Social isolation affects the brain and behavior in a variety of animals, including humans. Studies in traditional laboratory rodents, including mice and rats, have supported the idea that short-term social isolation promotes affiliative social behaviors,
Jesus E Madrid, Nicole M Pranic, Samantha Chu, Johanna J D Bergstrom, Rhea Singh, Joclin Rabinovich, Kaycee Arias Lopez, Alexander G Ophir, Katherine A Tschida   +8 more
doaj   +1 more source