Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Addressing the Ethical, Legal, and Social Issues of Healthtech in Education: Insights From Japan. [PDF]
JMIR Form ResSumiya M +7 more
europepmc +1 more source
Covid-19 and Sargassum blooms: impacts and social issues in a mass tourism destination (Mexican Caribbean). [PDF]
Marit Stud, 2022 Fraga J, Robledo D.
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Ethical, Legal, and Social Issues in Metaverse-Enabled Healthcare. [PDF]
Blockchain Healthc TodayKostick-Quenet KM, Rahimzadeh V.
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'The spiral just keeps on going': Cascading health and social issues for women living and aging with HIV. [PDF]
Womens Health (Lond), 2022 Herron LM +4 more
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Digital health interventions as a catalyst for change: A narrative review of the roles of digital health in enhancing well-being and reducing public health and social issues among sex workers. [PDF]
Digit HealthMokhwelepa LW, Sumbane GO.
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Addressing the social issues around vaccination could be the pivotal strategy to achieve the 2022 COVID-19 vaccination coverage target. [PDF]
Ann Med Surg (Lond), 2022 Ayeni GO, Idris IO, Adebisi YA.
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