Results 41 to 50 of about 134,161 (215)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Integrating life cycle assessment into green infrastructure: a systematic review and meta-analysis of urban sustainability strategies

Frontiers in Sustainable Cities
Green infrastructure (GI) is increasingly vital for cities addressing environmental challenges, climate change, and sustainability through nature-based solutions.
Negin Bani Khalifi, Dafni Despoina Avgoustaki, Thomas Bartzanas   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

LCSA Framework for Assessing Sustainability of Alternative Fuels for Transport Sector

Chemical Engineering Transactions, 2019
Consideration of alternative transport fuels, produced from feedstocks and renewable resources, is inevitable to enhance energy security and alleviate environmental burdens.
Najmul Hoque, Wahidul K. Biswas, Ilyas Mazhar, Ian Howard   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Social Life Cycle Assessment of Healthcare Waste Supply Chains

Environmental and Climate Technologies
Along with the growth of the healthcare waste (HCW) sector, the significance of properly managed waste generated in medical institutions has also grown, both to protect public health and to ensure sustainability.
Gusca Julija, Kondratenko Inga, Zlaugotne Beate, Pubule Jelena, Zandberga Anda, Kalnins Silvija Nora   +5 more
doaj   +1 more source

CONSIDERATION OF PAVEMENT TYPE SERVICE LIFE CAPACITY FOR SUSTAINABLE INFRASTRUCTURE DEVELOPMENT IN NIGERIA

Journal of Construction Project Management and Innovation, 2019
The opposition over the use of concrete pavement against the conventional flexible pavement in Nigeria cannot be overemphasized; nevertheless, the question of interest should be: is concrete pavement now a way out of Nigeria road network? Certainly, the
Samuel Olugbenga Abejide, Jacob Adebayo Adedeji, Moamed Mostafa   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Social life cycle assessment of food loss and waste: social impact considerations

Frontiers in Sustainable Food Systems
Reducing food loss and waste (FLW) is key to increasing the sustainability of food systems worldwide. The causes of FLW vary from on farm losses to distribution and consumption related waste.
Emi Kameyama, Sabine O’Hara, Marian Stuiver, Tsakani Ngomane   +3 more
doaj   +1 more source