Results 71 to 80 of about 7,776,710 (330)

The Influence of Social Capital on Knowledge Management Maturity of Nonprofit Organizations – Predictive Modelling Based on a Multilevel Analysis

IEEE Access, 2019
Nonprofit, nongovernmental organizations (NGOs) are important development actors that operate in ecosystems of multi and cross-sector stakeholders in order to reach the most vulnerable social groups of people. Having this in mind, our goal was to explore
Radmila Mikovic, Branko Arsic, Dorde Gligorijevic, Marija Gacic, Dejan Petrovic, Nenad Filipovic   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

NEUROPSYCHIC AND SOCIAL ASPECTS OF READINESS FOR THE SCHOOL EDUCATION OF PREPARATORY GROUP CHILDREN IN PRESCHOOL EDUCATIONAL INSTITUTIONS

Мать и дитя в Кузбассе, 2022
The aim of the investigation is to study neuropsychic and social aspects of children’s school maturity. The research considers 7 year-old children in preparatory groups of preschool educational institutions in Kemerovo. Materials and methods.
Илья Александрович Селиверстов, Нина Константиновна Перевощикова, Наталья Петровна Крекова, Светлана Альбертовна Дракина, Наталья Степановна Черных   +4 more
doaj  

All for one: Contributions of age, socioeconomic factors, executive functioning and social cognition to moral reasoning in childhood.

Frontiers in Psychology, 2016
Moral reasoning (MR) is a sociocognitive skill essential to appropriate social functioning in childhood, and evolves in quality and complexity during ontogenetic development. Whereas past research suggests that MR is related to age, socioeconomic factors,
Evelyn eVera-Estay, Evelyn eVera-Estay, Anne G Seni, Caroline eChampagne, Miriam H Beauchamp, Miriam H Beauchamp   +5 more
doaj   +1 more source

The Mediating Role of Internet usage on Social Maturity of Young Adults

, 2021
Ayesha Arshi, Anjali Sahai
openalex   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The influence of executive function therapy on improving social maturity in children with Attention Deficit Hyperactivity Disorder (ADHD): An experimental study

Psikohumaniora: Jurnal Penelitian Psikologi
Children with Attention Deficit Hyperactivity Disorder (ADHD) have non-adaptive behavioral problems related to social maturity, which impact their future lives as adults, thus necessitating access to appropriate treatment. This experimental study aims to
Taufik Hidayat, Imadduddin Imadduddin, Maha Al-Hendawi, Abdullah Azzam Al Afghani   +3 more
doaj   +1 more source

Perbedaan Kemampuan Bersosialisasi dan Kematangan Emosional Anak PAUD dan Non PAUD

Jurnal Berita Ilmu Keperawatan, 2018
Social development is a process of learning to adjust to the morals, traditions, norms and communicate with each other and work together to reach maturity in social relations.
Dian Afriyanto, Siti Arifah
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source