Results 101 to 110 of about 14,460,445 (383)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

GraphOptima: A graph layout optimization framework for visualizing large networks

SoftwareX
Graphs illustrating online networks, participants, and interactions have become essential tools for studying issues like misinformation, botnets, algorithmic filtering and many other areas of research.
Anatoliy Gruzd, Jingwei Zhang, Philip Mai   +2 more
doaj   +1 more source

Organizational Communication and Conflict Management Systems

Nordicom Review, 2010
The purpose of the present article is to examine the prevailing model of systematic organizational conflict management from an organizational communicative perspective and to suggest directions for improvement.
Aula Pekka, Siira Kalle
doaj   +1 more source

Teens, Social Media, and Privacy [PDF]

, 2013
Teens share a wide range of information about themselves on social media sites; indeed the sites themselves are designed to encourage the sharing of information and the expansion of networks.
Aaron Smith, Amanda Lenhart, Maeve Duggan, Mary Madden, Meredith Beaton, Sandra Cortesi, Urs Gasser   +6 more
core  

Leveraging Social Foci for Information Seeking in Social Media [PDF]

, 2015
The rise of social media provides a great opportunity for people to reach out to their social connections to satisfy their information needs. However, generic social media platforms are not explicitly designed to assist information seeking of users.
Hu, Xia, Liu, Huan, Ranganath, Suhas, Sundaram, Hari, Tang, Jiliang   +4 more
core   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Listen to the Scientists: Effects of Exposure to Scientists and General Media Consumption on Cognitive, Affective, and Behavioral Mechanisms During the COVID-19 Pandemic

Human Behavior and Emerging Technologies
Throughout the COVID-19 crisis, scientists around the globe have engaged in science communication to an unprecedented degree to convey first-hand epidemiological knowledge and information on preventive measures.
Jessica M. Szczuka, Judith Meinert, Nicole C. Krämer   +2 more
doaj   +1 more source

Catalyzing social media scholarship with open tools and data [PDF]

Journal of Contemporary Eastern Asia, 2015
Social media comprises a vast and consequential landscape that has been poorly mapped and understood. Hundreds of millions of people have eagerly moved many of the conversations and discussions that compose civil society into these services and platforms.
Marc A. Smith
doaj   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source