Results 51 to 60 of about 672,505 (264)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Listen to the Scientists: Effects of Exposure to Scientists and General Media Consumption on Cognitive, Affective, and Behavioral Mechanisms During the COVID-19 Pandemic

Human Behavior and Emerging Technologies
Throughout the COVID-19 crisis, scientists around the globe have engaged in science communication to an unprecedented degree to convey first-hand epidemiological knowledge and information on preventive measures.
Jessica M. Szczuka, Judith Meinert, Nicole C. Krämer   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Evaluating the impact of open access policies on research institutions

eLife, 2020
The proportion of research outputs published in open access journals or made available on other freely-accessible platforms has increased over the past two decades, driven largely by funder mandates, institutional policies, grass-roots advocacy, and ...
Chun-Kai (Karl) Huang, Cameron Neylon, Richard Hosking, Lucy Montgomery, Katie S Wilson, Alkim Ozaygen, Chloe Brookes-Kenworthy   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

GraphOptima: A graph layout optimization framework for visualizing large networks

SoftwareX
Graphs illustrating online networks, participants, and interactions have become essential tools for studying issues like misinformation, botnets, algorithmic filtering and many other areas of research.
Anatoliy Gruzd, Jingwei Zhang, Philip Mai   +2 more
doaj   +1 more source

Organizational Communication and Conflict Management Systems

Nordicom Review, 2010
The purpose of the present article is to examine the prevailing model of systematic organizational conflict management from an organizational communicative perspective and to suggest directions for improvement.
Aula Pekka, Siira Kalle
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Examining the Varied Effects of Social Media on Body Image Across Genders: An In-Depth Systematic Review

SAGE Open
This systematic review investigates the relationship between social media use and body image across genders, examining how different engagement patterns influence body perception and identifying gender-specific vulnerability factors through the ...
Jiaqing Xu, Mumtaz Aini Alivi, Siti Ezaleila Binti Mustafa, Nasrullah Dharejo, Maria Brony, Wang Haoyue   +5 more
doaj   +1 more source