Results 111 to 120 of about 27,898,979 (247)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Representing Addiction in Contemporary Media [PDF]
openThis thesis explores the multifaceted representations of addiction in various media with the aim of shedding light on the complex socio-cultural implications of these representations.
CHMIELARCZYK, MILENA
core
Social Media Addiction Scale for Adolescents: Validity and Reliability Study
Addicta: The Turkish Journal on Addictions, 2019 Nowadays, technology and Internet use has been increasing, and this increase brings along social, psychological, and physical problems. Social media addiction is one of the problems that arise from intensive Internet and technology use.
Mustafa Özgenel +2 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Internet addiction and loneliness among children and adolescents in the education setting: an empirical pilot study [PDF]
, 2014 Research into various behavioural addictions has shown that such behaviour can negatively impact psychological wellbeing. One behavioural addiction that has been increasingly studied empirically is that of Internet Addiction (IA).
Griffiths, M.D. +5 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Narcissism, Social Media Addiction, Self-Esteem, and Haxeco Traits: Exploring Influences on Life Satisfaction Among Generation Z [PDF]
Thanh Ngoc Dan Nguyen,1 Hao Yen Tran,2 Giang Hoang Minh Nguyen,2 Yen Kim Nguyen,2 Hoai Thi Mong Dinh2 1Faculty of Business Administration, Ho Chi Minh City Open University, Ho Chi Minh City, Vietnam; 2School of Advanced Study, Ho Chi Minh City Open ...
Nguyen YK +4 more
core
Gaming addiction in adolescence (revisited) [PDF]
, 2014 Gaming addiction has become a topic of increasing research interest. Over the last 25 years, I have written many articles on adolescent video gaming for Education and Health as it is one of the research fields that is constantly evolving.
Griffiths, MD
core
Social media addiction and depression among adolescents in two Malaysian states
International Journal of Adolescence and YouthAddiction to social media addiction is considered a leading risk factor for depression among adolescents, but the relationship needs to be supported empirically. This study investigates the social media addiction level and its association with depression
Stephanie Ann Victor +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source