Results 91 to 100 of about 42,904 (255)

Social media addiction is a new smoking

Annals of Psychophysiology, 2018
Background: Addiction is the behavior of a human in which they depend fully on the substance. According to the World Health Organization (WHO) 2015, over 1.1 billion people smoked tobacco whereas; over 2.14 billion people used social networks. The objective of this study is to assess that is there any similarity between the addiction level of smoking ...
Sonya Arshad, Muhammad Faisal Qureshi, Syed Hasan Abbas Rizvi, Bakhtawar Ferozali, Sidra Abdul Majeed, Summaya Khan, Haziq Ajaz   +6 more
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Addictive motivational scaffolds and the structure of social media

Synthese
Abstract In this paper, I propose an account of behavioral addiction in terms of what I call addictive motivational scaffolds (AMSs). Taking inspiration from recent work concerning psychiatric externalism and addiction, I propose and describe the concept of motivational scaffolding: external structure that ...
openaire   +3 more sources

Development of the Social Media Addiction Scale

AJIT-e Online Academic Journal of Information Technology, 2015
In this research, it was aimed to develop a scale to detect the social media addiction of university students. The data collected from 775 university students revealed that the scale was composed of four factors. Of these four factors, the first one called as “occupation” explained itself 17% of the variance, the second one called as “mood modification”
TUTGUN-ÜNAL, Aylin, DENİZ, Levent
openaire   +4 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Social media addiction and depression among adolescents in two Malaysian states

International Journal of Adolescence and Youth
Addiction to social media addiction is considered a leading risk factor for depression among adolescents, but the relationship needs to be supported empirically. This study investigates the social media addiction level and its association with depression
Stephanie Ann Victor, Muhamad Shamsul Ibrahim, Sarina Yusuf, Norasyikin Mahmud, Khairul Azam Bahari, Loh Yoke Ling, Nur Nadia Abd Mubin   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Investigation of the Risk of Social Media Addiction and Individual-Social Problems in Adolescents

Psikiyatride Güncel Yaklaşımlar
Objective: This study aimed to investigate the relationship between social media addiction and individual as well as social problems in adolescents. Method: A cross-sectional, relational design was employed from October 2020 to October 2021, involving ...
Damla Duman, Nazan Turan
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source