Results 41 to 50 of about 42,884 (256)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Mediating Role of Self-Esteem Between Meaning in Life and Social Media Addiction
Addicta: The Turkish Journal on AddictionsThe advent of digital technologies has markedly transformed human interactions and communication. While social media platforms facilitate connectivity and information sharing, their compelling features, such as instant notifications and one-click ...
Berhan Akdağ, Cansu Ünsal
doaj +1 more source
Addicta: The Turkish Journal on Addictions, 2018 Social media usage and smartphone addiction vary according to gender, Internet access plan, and smartphone ownership. In childhood, uncontrolled social media usage opens the way to cases of smartphone addiction.
Fikret Sözbilir +1 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Indian Journal of Community Medicine, 2018 Introduction: Social Media usage is a “global consumer phenomenon” with an exponential rise within the past few years. The use of social media websites is among the common activity for today's adolescents, they are sometimes overused/misused, which may ...
N R Ramesh Masthi +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Treatment for social media addiction with hypnotic-oriented counseling
Discover PsychologyBackground Research has identified social media addiction as a new and often unrecognized clinical disorder that impacts users' ability to control social media use which can lead to relational, work, and social problems.
Gian Sugiana Sugara, Rikza Fadhilah
doaj +1 more source
Dark triad and social media addiction: A meta-analysis
Klinik Psikoloji DergisiThe dark triad consists of three personality traits including narcissism, Machiavellianism, and psychopathy. Social media addiction is defined as individuals’ losing control over social media use and thus experiencing negative reflections on academic ...
Bilal Kaya
doaj +1 more source