Results 61 to 70 of about 28,036,793 (273)

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Social media invloed en reputatie: de identificatie van invloed binnen social media [PDF]

, 2012
Social media is een fenomeen waarvan de waarde voor organisaties niet meer wordt betwist. Betrokken binnen het bedrijfsleven erkennen het allemaal, social media spelen een rol of gaan een grote rol spelen binnen de corporate communicatie.
de Vries, Sjoerd A., Constantinides, Efthymios; id_orcid, Constantinides, Efthymios, Vollenbroek, Wouter Bernardus   +3 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Don’t Want It Anymore? Resilience as a Shield Against Social Media-Induced Overloads

, 2021
Social media have become part of millions of users’ everyday life, leading to the proliferation of the daily stressors associated with them, particularly social media-induced overloads. Therefore, understanding the individual characteristics that enable users to resist such stress factors and ultimately buffer negative follow-up effects, such as ...
Alena Bermes, Clara-Lea Gromek
openaire   +3 more sources

Do you regret using social media? Understanding the role of dark side of social media in regret and discontinuance behavior [PDF]

, 2019
Social media is designed to support interpersonal communication and collaboration via Internet-based platforms. Despite the popularity of social media technologies, people spent less time on social media sites and their usage patterns changed ...
Huang, Ziyue, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

The death of Jill Meagher: crime and punishment on social media [PDF]

, 2014
This paper aims to identify and analyse several predominant issues and discourses as they relate to the burgeoning interrelationship between social media, crime and victim.
Milivojevic, Sanja, McGovern, Alyce, Sanja Milivojevic, Alyce McGovern, Milivojevic, S., McGovern, A.   +5 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Study on the Influence Mechanism of Sensory Overload on Social Media Fatigue

DEStech Transactions on Social Science, Education and Human Science, 2019
Social media fatigue is the decline of users' negative emotional experience and behavioral intention in the use of social media, which will lead to the rapid loss of social media users. In this paper, online sense of control and psychological resilience are taken as mediating and regulating variables respectively, and the influence mechanism of ...
Ying-hao LI, Teng-teng WANG, Chun-yu XU
openaire   +2 more sources

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source