Results 101 to 110 of about 730,214 (312)

Social PR study 2015: a study of social media use among PR professionals [PDF]

, 2015
This study aims to explore and understand how social media impacts PR professionals and their media relationships. It compares the results with research from the published Social Journalism Study 2015 and notes that PR professionals and journalists are ...
Cision UK, Pole, K.
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Problematic Social Media Use or Social Media Addiction in Pediatric Populations

Pediatric Clinics of North America
With the advent of smartphones and the popularization of social media sites at the beginning of the twenty-first century, children and adolescents have been exposed to a world of virtual interactions in social networking sites that are designed to increase engagement of the user for profit.
Vidal, Carol, Sussman, Clifford
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Irritability and Social Media Use in US Adults

JAMA Network Open
ImportanceEfforts to understand the complex association between social media use and mental health have focused on depression, with little investigation of other forms of negative affect, such as irritability and anxiety.ObjectiveTo characterize the association between self-reported use of individual social media platforms and irritability among US ...
Perlis, Roy H., Uslu, Ata, Schulman, Jonathan, Gunning, Faith M., Santillana, Mauricio, Baum, Matthew A., Druckman, James N., Ognyanova, Katherine, Lazer, David   +8 more
openaire   +3 more sources

Affective Body Politics of Social Media [PDF]

In this introduction to special issue, we elaborate our use of the concept affective body politics in the context of social media. Bringing together two theoretical concepts, the notion of “body politics” and that of “affective politics,” we direct ...
Susanna Paasonen, Mari Lehto, Kaisu Hynnä   +2 more
core   +1 more source

Social Media in Educational Practice: Faculty Present and Future Use of Social Media in Teaching [PDF]

, 2017
This paper presents results from a questionnaire (n=333) designed to gain an understanding of instructor motivations and experience with social media use in educational practice.
Esteve Del Valle, Marc; id_orcid, Esteve Del Valle, Marc, Drew Paulin, Haythornthwaite, Caroline, Gruzd, Anatoliy, Anatoliy Gruzd, Sarah Gilbert, Caroline Haythornthwaite, Paulin, Drew, Gilbert, Sarah, Marc Esteve Del Valle   +10 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Not Feeling It: Modifiable Correlates of Anhedonia

Behavioral Sciences
Background: Anhedonia denotes a reduced capacity of experiencing pleasure, which is often reported by individuals with psychiatric disorders such as depression and polysubstance use disorders.
Marina F. Thomas, Gloria Mittmann, Marie Celine Dorczok, Verena Steiner-Hofbauer   +3 more
doaj   +1 more source