Results 71 to 80 of about 12,155,964 (381)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

THE SOCIAL TREND IN MEDICINE [PDF]

Journal of the American Medical Association, 1920
ABSTRACT Before the war, a new era made itself known in many ways; but medicine, especially in the United States, either held aloof or, at any rate, did not actively face the facts. Many things included under the term socialization affected medical practice as well as medical study.
openaire   +2 more sources

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Effective uses of social media in public health and medicine: a systematic review of systematic reviews

Online Journal of Public Health Informatics, 2018
Introduction Research examining the effective uses of social media (SM) in public health and medicine, especially in the form of systematic reviews (SRs), has grown considerably in the past decade.
D. Giustini, Syed Mustafa Ali, M. Fraser, M. Boulos   +3 more
semanticscholar   +1 more source

Los Cuadernos Médico Sociales de Rosario y las revistas de la medicina social latinoamericana entre las décadas de 1970 y 1980

História, Ciências, Saúde: Manguinhos
Resumen Entre 1970 y 1980, fueron creadas un conjunto de revistas con el objetivo de difundir las ideas de la medicina social latinoamericana en distintos países del continente, en una etapa temprana en la institucionalización de este movimiento que ...
Hugo Spinelli, Juan Martín Librandi, Juan Pablo Zabala   +2 more
doaj   +1 more source

Arbeit, Lebenserwartung, Geschlecht: Wien 1900–1950

Österreichische Zeitschrift für Geschichtswissenschaften, 2011
Medical discourse in the 1920s in Germany and Austria produced a significant increase in papers and monographs dealing with the links between female health and women at work. This hype vanished in the Austrofascist and Nazi-Era, when, because of ideology,
Andreas Weigl
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Carsey Perspectives: Meeting Farmers Where They Are, Increasing Agricultural Sustainability in Malawi Through Business Format Franchising [PDF]

, 2017
In this perspectives brief, authors Ilona Drew, Abraham DeMaio, Bill Maddocks, and Fiona Wilson discuss a case study that was examined as part of the Social Sector Franchise Initiative (SSFI), a project of the Center for Social Innovation and Enterprise ...
DeMaio, Abraham, Drew, Ilona, Maddocks, William, Wilson, Fiona   +3 more
core   +1 more source

Development of Model of Stage Health Care System for Patients with Bronchopulmonary Dysplasia. Stage I: Determining the Need for Regional Centers for Diagnosis and Treatment

Galician Medical Journal, 2016
Graphical and polynomial (quantitative) regional model of bronchopulmonary dysplasia (BPD) prevalence, depending on the number of premature children, was substantiated, composed and proposed for use for the first time.
A. F. Shypko
doaj  

Centros de Saúde: ciência e ideologia na reordenação da saúde pública no século XX Health Centers: science and ideology in the re-organization of public health in the twentieth century

História, Ciências, Saúde: Manguinhos, 2011
Os Centros de Saúde surgem nos EUA em torno de 1910, com caráter de assistência social adida a algum serviço médico. Sua separação inicial entre medicina preventiva e curativa foi superada pela medicina integral na década de 1940, quando o discurso dos ...
Guilherme Arantes Mello, Ana Luiza d'Ávila Viana   +1 more
doaj   +1 more source