Results 101 to 110 of about 530,519 (305)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The transformation of provisioning systems from an integrated perspective of social metabolism and political economy: a conceptual framework. [PDF]
Sustain Sci, 2021 Schaffartzik A +5 more
europepmc +1 more source
A comparison of circuit training and high intensity interval training for population health [PDF]
, 2012 Thesis (M.A.)--Boston UniversityIn the fast-paced lifestyle of modern-day society, people often feel overwhelmed by their list of things to do. It is no surprise then that a lot of people claim that they have "no time" to exercise.
Chan, Elizabeth
core +1 more source
Sex assignment in conditions affecting sex development [PDF]
, 2017 The newborn infant with atypical genitalia presents a challenging clinical scenario and requires expert input. There have been appreciable advances in our knowledge of the underlying causes that may lead to a mere difference or a more serious disorder of
Ahmed, S. Faisal, Markosyan, Renata
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Clinical Medicine Insights: Endocrinology and Diabetes, 2011 Combined pegylated interferon (PEG-IFN)+ribavirin (RBV) therapy has been used as a primary treatment for chronic hepatitis C. However, IFN-induced autoimmune disease, including type 1 diabetes mellitus, has been highlighted as one of the problems with ...
Reiko Oka +5 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
International Journal of Behavioral Nutrition and Physical Activity, 2018 Background Metabolic health in people with obesity is determined by body composition. In this study, we examined the influence of a combined strength exercise and motivational programme –embedded in the school curriculum– on adolescents body composition ...
G. A. Ten Hoor +10 more
doaj +1 more source
GPS analysis of a team competing at a national Under 18 field hockey tournament [PDF]
, 2018 The purpose of this study was to utilise global-positioning system (GPS) technology to quantify the running demands of national Under 18 field hockey players competing in a regional field hockey tournament.
Van der Merwe, Frans H
core
Metabolomics-based biomarker discovery for bee health monitoring : a proof of concept study concerning nutritional stress in Bombus terrestris [PDF]
, 2019 Bee pollinators are exposed to multiple natural and anthropogenic stressors. Understanding the effects of a single stressor in the complex environmental context of antagonistic/synergistic interactions is critical to pollinator monitoring and may serve ...
Meeus, Ivan +5 more
core +2 more sources