Results 51 to 60 of about 222,824 (299)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Vocational education in the academic drift or arrogance of academia in front of planetary crisis

Nordic Journal of Vocational Education and Training
The article questions the feasibility of the universalist discourse on academic drift in vocational education from the perspective of the Global North-South configuration.
Mohammed Asaduzzaman, Anja Heikkinen, Santeri Sorsa, Pamela Wadende   +3 more
doaj   +1 more source

Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood

Genes and Diseases, 2019
Overfeeding in early life is associated with obesity and insulin resistance in adulthood. In the present study, a well-characterized mouse model was used to investigate whether neonatal overfeeding increases susceptibility to the development of non ...
Juan Du, Xuemei Cao, Junlin Diao, Qijuan Zhang, Chuan Peng, Jibin Li, Xiaoqiu Xiao   +6 more
doaj   +1 more source

Effect of temperature and glia in brain size enlargement and origin of allometric body-brain size scaling in vertebrates [PDF]

, 2014
Background: Brain signaling requires energy. The cost of maintaining and supporting energetically demanding neurons is the key constraint on brain size.
Feng, Jianfeng, Jianfeng Feng, Sachdev, Robert, Karbowski, Jan, Yu, Yuguo, Jan Karbowski, Yuguo Yu, Robert NS Sachdev   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Periconceptional folic acid supplementation: Knowledge, attitudes and counselling practice of Serbian pharmacists and pharmacy technicians [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. The protective effect of periconceptional folic acid supplementation in reducing the risk of neural tube defects (NTDs) and other adverse pregnancy outcomes has been scientifically confirmed.
Zeković Milica, Krajnović Dušanka, Nikolić Marina, Stojković Tatjana, Gurinović Mirjana, Glibetić Marija   +5 more
doaj   +1 more source

Social metabolism and bioeconomy Dialogue of knowledge

Apuntes de economía y sociedad, 2021
The general objective of the article is to characterize two analytical categories such as social metabolism and bioeconomy from the perspective of ecological economics as bridges for discussion, critique, and solution of the problems of the 21st century.
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Low physical activity is the strongest factor associated with frailty phenotype and frailty index: data from baseline phase of Birjand Longitudinal Aging Study (BLAS)

BMC Geriatrics, 2022
Background Frailty is the most complicated expression of aging that is related to disability or multi-morbidity. The aim of the present study was to estimate the prevalence of frailty and its associated factors among community-dwelling aged population ...
Ameneh Sobhani, Farshad Sharifi, Reza Fadayevatan, Ahmad Ali Akbari Kamrani, Mitra Moodi, Masoumeh Khorashadizadeh, Toba Kazemi, Huriye Khodabakhshi, Hossein Fakhrzadeh, Masoud Arzaghi, Seyedeh Zahra Badrkhahan, Raziye Sadat Hosseini, Hadi Monji, Amirabbas Nikkhah   +13 more
doaj   +1 more source