Results 61 to 70 of about 212,164 (260)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Gestational diabetes knowledge improves with interactive online training modules

BMC Medical Education
Background The risk of developing type 2 diabetes mellitus (T2DM) is up to 50% among women with gestational diabetes mellitus (GDM). However, diabetes education during and after pregnancy is limited.
Petra Krutilova, Roxann Williams, Rebecca Morey, Carole Field, Veronda Byrth, Melissa Tepe, Amy McQueen, Cynthia Herrick   +7 more
doaj   +1 more source

Social Metabolism and Biodiversity

Socio-metabolic research investigates societies’ extraction of raw materials and energy from the environment, their transformation into products, biophysical trade flows, the accumulation of societal material stocks (buildings, infrastructures, long-lived products), biophysical aspects of consumption, and releases of emissions and wastes to the ...
Haberl, Helmut, Erb, Karlheinz, Gaube, Veronika, Krausmann, Fridolin, Matej, Sarah   +4 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Intelligent technology-driven diabetes prevention and control: From informatization management to artificial intelligence

Science Progress
The escalating prevalence of diabetes, along with its complications and mortality risks, imposes a substantial disease burden worldwide. The current suboptimal medical conditions and poor self-management among diabetic patients have exacerbated the ...
Geer Deng, Wang Chengshi
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The transformation of provisioning systems from an integrated perspective of social metabolism and political economy: a conceptual framework. [PDF]

Sustain Sci, 2021
Schaffartzik A, Pichler M, Pineault E, Wiedenhofer D, Gross R, Haberl H.   +5 more
europepmc   +1 more source

Steroid Metabolism and the Activation of Social Behavior

, 1989
Within a number of endocrine structures including the gonads, the adrenals, and the placenta, cholesterol is transformed into several compounds that are generally referred to as steroids. Steroids are compounds which have a molecular weight of about 300 and share with cholesterol the cyclopentano-phenanthrene nucleus (three C6 and one C5 ring; see Fig.
openaire   +2 more sources