Results 61 to 70 of about 530,519 (305)

Linking sociometabolic stress to strong sustainability: a framework for assessing societal transformations

Global Sustainability
Non-technical summary Sustainability transformations necessitate systemic changes that simultaneously respect planetary boundaries and promote social equity.
Jarkko Levänen, Lassi Linnanen, Kevin Dillman, Jukka Heinonen   +3 more
doaj   +1 more source

Elevated glutamatergic compounds in pregenual anterior cingulate in pediatric autism spectrum disorder demonstrated by 1H MRS and 1H MRSI. [PDF]

, 2012
Recent research in autism spectrum disorder (ASD) has aroused interest in anterior cingulate cortex and in the neurometabolite glutamate. We report two studies of pregenual anterior cingulate cortex (pACC) in pediatric ASD.
Alger, Jeffry R, Bejjani, Anthony, Frew, Andrew J, Kim, John A, Kitchen, Christina, Levitt, Jennifer G, Ly, Ronald, McCracken, James T, O'Neill, Joseph, Salamon, Noriko, Toga, Arthur W, Yee, Victor W   +11 more
core   +2 more sources

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]

, 2020
Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher, Dorrestein, Pieter C, Jarmusch, Alan K, Knight, Rob, Liyanage, Marlon, Ma, Joseph D, Momper, Jeremiah D, Tsunoda, Shirley M, Vrbanac, Alison   +8 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Trapped or staying put: Governing immobility in the context of climate change

Frontiers in Climate, 2023
By presenting a range of outcomes which result from the impacts of a changing environment on human mobility patterns, the Foresight Report on Migration and Global Environmental Change emphasized that, whereas some people choose to stay in a specific ...
Fanny Thornton, Fanny Thornton, Diogo Andreolla Serraglio, Diogo Andreolla Serraglio, Alec Thornton, Alec Thornton   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Periconceptional folic acid supplementation: Knowledge, attitudes and counselling practice of Serbian pharmacists and pharmacy technicians [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. The protective effect of periconceptional folic acid supplementation in reducing the risk of neural tube defects (NTDs) and other adverse pregnancy outcomes has been scientifically confirmed.
Zeković Milica, Krajnović Dušanka, Nikolić Marina, Stojković Tatjana, Gurinović Mirjana, Glibetić Marija   +5 more
doaj   +1 more source

Are UK Policies and Practices for Regulated Donor Insemination Forcing Women to Find Unregulated Sperm Donors Online? A Perspective on the Available Evidence

Frontiers in Global Women's Health, 2022
In recent years, there has been an increase in women obtaining donor sperm via unregulated websites and social media. In this article, we bring together the disparate evidence in this emerging field to consider whether restrictive UK policies and ...
Francesca Taylor, Rhys Turner-Moore, Allan Pacey, Georgina Louise Jones   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Low physical activity is the strongest factor associated with frailty phenotype and frailty index: data from baseline phase of Birjand Longitudinal Aging Study (BLAS)

BMC Geriatrics, 2022
Background Frailty is the most complicated expression of aging that is related to disability or multi-morbidity. The aim of the present study was to estimate the prevalence of frailty and its associated factors among community-dwelling aged population ...
Ameneh Sobhani, Farshad Sharifi, Reza Fadayevatan, Ahmad Ali Akbari Kamrani, Mitra Moodi, Masoumeh Khorashadizadeh, Toba Kazemi, Huriye Khodabakhshi, Hossein Fakhrzadeh, Masoud Arzaghi, Seyedeh Zahra Badrkhahan, Raziye Sadat Hosseini, Hadi Monji, Amirabbas Nikkhah   +13 more
doaj   +1 more source