Results 31 to 40 of about 1,271,862 (339)

Spatial Mobility in Social Theory

open access: yesSocietàMutamentoPolitica: Rivista Italiana di Sociologia, 2020
While the concept of ‘mobility’ lends itself to a variety of metaphorical meanings, ‘spatial mobility’ is in fact poorly theorized in the history of sociology. Nonetheless, it plays an underrated role in the theories of all the classics of the discipline:
Ettore Recchi, Aurore Flipo
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Syntax comprehension in Persian-speaking students with ADHD

open access: yesBMC Psychiatry
Background Syntax is one of the most intricate domains of language, and as such, offers valuable insights into language processing in typical and neurodiverse populations.
Armon Massoodi   +8 more
doaj   +1 more source

More than Money: Social Class, Income, and the Intergenerational Persistence of Advantage

open access: yesSociological Science, 2017
I provide a uniquely comprehensive empirical integration of the sociological and economic approaches to the intergenerational transmission of advantage.
Carina Mood
doaj   +1 more source

Education and Social Fluidity: A Reweighting Approach

open access: yesSociological Science, 2022
Although sociologists have devoted considerable attention to studying the role of education in intergenerational social class mobility using log-linear models for contingency tables, indings in this literature are not free from rescaling or non ...
Kristian Bernt Karlson
doaj   +1 more source

Social Mobility and Demand for Redistribution. A Comparative Analysis [PDF]

open access: yes, 2016
The literature on preferences for redistribution has paid little attention to the effect of social mobility on the demand for redistribution, which is in contrast with the literature on class-voting, where studies on the effect of social mobility has ...
Jaime-Castillo, Antonio Manuel   +1 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Intergenerational mobility in England, 1858-2012. Wealth, surnames, and social mobility [PDF]

open access: yes, 2013
This paper uses a panel of 21,618 people with rare surnames whose wealth is observed at death in England and Wales 1858-2012 to measure the intergeneration elasticity of wealth over five generations.
Clark, Gregory, Cummins, Neil
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

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