Results 31 to 40 of about 1,270,077 (292)
Advances in Electrical and Electronic Engineering, 2017 In this paper, are described the basics of Social Based Mobility Model inspired by mobility of students alongside with Metrics for Evaluation of Social Behaviour in Mobility Models for MANET-DTN networks.
David Hrabcak +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Social Mobility and Demand for Redistribution. A Comparative Analysis [PDF]
, 2016 The literature on preferences for redistribution has paid little attention to the effect of social mobility on the demand for redistribution, which is in contrast with the literature on class-voting, where studies on the effect of social mobility has ...
Jaime-Castillo, Antonio Manuel +1 more
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
European Transport Research ReviewThis paper explores the role of indicators in urban mobility governance, analysing their effects based on qualitative interviews with experts in policymaking and planning from the German Rhine-Main region.
Julius Bücher
doaj +1 more source
Intergenerational mobility in England, 1858-2012. Wealth, surnames, and social mobility [PDF]
, 2013 This paper uses a panel of 21,618 people with rare surnames whose wealth is observed at death in England and Wales 1858-2012 to measure the intergeneration elasticity of wealth over five generations.
Clark, Gregory, Cummins, Neil
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Syntax comprehension in Persian-speaking students with ADHD
BMC PsychiatryBackground Syntax is one of the most intricate domains of language, and as such, offers valuable insights into language processing in typical and neurodiverse populations.
Armon Massoodi +8 more
doaj +1 more source
More than Money: Social Class, Income, and the Intergenerational Persistence of Advantage
Sociological Science, 2017 I provide a uniquely comprehensive empirical integration of the sociological and economic approaches to the intergenerational transmission of advantage.
Carina Mood
doaj +1 more source