Results 31 to 40 of about 198,282 (295)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Spatial Mobility in Social Theory

open access: yesSocietàMutamentoPolitica: Rivista Italiana di Sociologia, 2020
While the concept of ‘mobility’ lends itself to a variety of metaphorical meanings, ‘spatial mobility’ is in fact poorly theorized in the history of sociology. Nonetheless, it plays an underrated role in the theories of all the classics of the discipline:
Ettore Recchi, Aurore Flipo
doaj   +1 more source

Social mobility and partnering. The salience of mobility homogamy

open access: yesSocial Science Research, 2023
Does intergenerational social mobility influence individuals' partner choices? If so, are the socially mobile more likely to partner with someone from their origin or destination class? Or do they, if torn between the socio-cultural milieu of their well-known origins and less familiar destination, engage in 'mobility homogamy', opting for similarly ...
Esping-Andersen, Gøsta   +2 more
openaire   +3 more sources

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

More than Money: Social Class, Income, and the Intergenerational Persistence of Advantage

open access: yesSociological Science, 2017
I provide a uniquely comprehensive empirical integration of the sociological and economic approaches to the intergenerational transmission of advantage.
Carina Mood
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

La movilidad social en Buenos Aires y Montevideo de 1960 a 2012

open access: yesEMPIRIA: Revista de Metodología de Ciencias Sociales, 2022
Este trabajo compara la movilidad social en Buenos Aires y Montevideo en un período de 50 años, en base a las encuestas de movilidad social más antiguas y más recientes en cada una de ellas.
Marcelo Boado Martínez
doaj   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Syntax comprehension in Persian-speaking students with ADHD

open access: yesBMC Psychiatry
Background Syntax is one of the most intricate domains of language, and as such, offers valuable insights into language processing in typical and neurodiverse populations.
Armon Massoodi   +8 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

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