Results 31 to 40 of about 18,472 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

PROTEST ACTIVITY AS A RESULT OF THE DEVALUATION OF CIVIL-POWER CONSENSUS (CASE OF THE STAVROPOL TERRITORY)

Современная наука и инновации, 2022
The article, based on the results of the author's sociological research, addresses the problem of protest moods in the Stavropol Territory. It justifies the idea that civilian activity is influenced by processes associated with the conclusion ...
G. V. Kosov, A. E. Gapich, O. V. Minkina
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Spreading of healthy mood in adolescent social networks [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2015
Depression is a major public health concern worldwide. There is evidence that social support and befriending influence mental health, and an improved understanding of the social processes that drive depression has the potential to bring significant public health benefits.
Hill, E. M., Griffiths, F. E., House, T.; id_orcid 0000-0001-5835-8062   +2 more
openaire   +3 more sources

The Role of Biopsychosocial Factors on Elderly Depression in Indonesia: Data Analysis of the Indonesian Family Life Survey Wave 5

Proceedings, 2022
Many factors trigger depression in the elderly; therefore, the role of biopsychosocial factors is considered a holistic study that is interrelated. We examined the relationship between sex, marital status, attachment, affect, religiosity, and social ...
Nia Murniati, Sudijanto Kamso
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Therapeutic outcomes of GnRHa and rhGH in idiopathic central precocious puberty: a focus on psychological and behavioral improvements

BMC Pediatrics
Objective The psychological issues associated with idiopathic central precocious puberty (ICPP) in girls remain a contentious topic, particularly regarding the necessity and effectiveness of psychological interventions and pharmacological treatments such
Jiao Chen, Lihong Cao, Xiaosa Chen, Xinjuan Zhou, Qingqing Yu, Wenqian Yang, Hong Chen   +6 more
doaj   +1 more source