Results 41 to 50 of about 18,897 (264)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
Georgia at the crossroads: for the analysis of social moods in the interelectoral period (2024-2025) [PDF]
Ante PortasThe paper aims at exploring and scrutinizing the mobility of the current social moods attributable to Georgia in one of its most determining times in the current history, i.e. in between two crucial elections – parliamentary elections of October 26, 2024,
Khatuna Chapichadze
doaj
Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro +6 more
wiley +1 more source
Genres as Social Affect: Cultivating Moods and Emotions through Playlists on Spotify
Social Media + Society, 2019 This article bridges work on media technologies and affect theories through an analysis of how users appropriate playlists on Spotify. Our study draws on 30 interviews with users of music streaming services in Costa Rica and an analysis of their accounts
Ignacio Siles +3 more
doaj +1 more source
Synesius, bishop of Ptolemais: Outline of the life and work [PDF]
Религия, церковь, общество, 2013 Synesius, bishop of Ptolemais, played an important role in the intellectual life of the Roman Empire on the turn of IV–V centuries. The article is devoted to the life and activity of Synesius in the context of his literary works that reflected the main ...
Olga Vladimirovna Przhigodzkaja
doaj +1 more source
Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino +25 more
wiley +1 more source
Ostium, 2019 Moods play a major role in Heidegger’s thought, as they open up the world to Dasein and permeate its entire existence, its possibilities of action, its very access to the world.
Beatrix Susanne Lepis
doaj
Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source
INTERVENTIONS IN SOCIAL NETWORKS: IMPACT ON MOOD AND NETWORK DYNAMICS [PDF]
Advances in Complex Systems, 2015 Results from two studies on longitudinal friendship networks are presented, exploring the impact of a gratitude intervention on positive and negative affect dynamics in a social network. The gratitude intervention had been previously shown to increase positive affect and decrease negative affect in an individual but dynamic group effects have not been
Danica Vukadinovic Greetham +3 more
openaire +4 more sources