Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Integration of Emerging Technologies into Social Networks
, 2020 Ion-Costel-Marius Bălţoi
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USE OF THE INTERNET AND SOCIAL NETWORKS IN ORTHOPEDICS AND TRAUMATOLOGY AND PERSPECTIVE OF POST COVID TELEMEDICINE [PDF]
, 2022 ALEXANDRE RAMOS ESTANISLAU +5 more
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Frontiers in PsychologyIntroductionWith the advent of the digital age, network literacy has become a pivotal indicator for assessing the social adaptability and quality of life among middle-aged and older adults.MethodsThis study is based on data from the Chinese Family Panel ...
Lin Sun, Juan Xiong, Chong Zhang
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Network Analysis of Association Between Problematic Social Network Use and Alexithymia in Freshmen
Psychology Research and Behavior ManagementLing Ding,1 Xuelian Ren,2 Yamei Sun,3 Chengjuan Yu,1 Ge Li,1 Chenggang Wang1 1School of Health, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 2Office of Academic Affairs, Heze University, Heze, Shandong,
Ding L, Ren X, Sun Y, Yu C, Li G, Wang C
doaj
Premenstrual dysphoric disorder in online peer support communities: a Reddit case study
Scientific ReportsThe growing reliance on online communities has reshaped how individuals articulate, validate, and navigate psychological distress. However, the value of online peer support spaces remains insufficiently studied, particularly in the context of ...
Bojan Evkoski +3 more
doaj +1 more source
ELITE - A Novel Ranking Algorithm for Social Networking Sites Using Generic Scoring Function [PDF]
, 2013 Khuan Lee, Jer Lang Hong
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SOCIAL NETWORK AND CAREGIVING EXPERIENCE AMONG SPOUSE AND ADULT-CHILD DEMENTIA CAREGIVERS: A MEDIATION ANALYSIS [PDF]
, 2023 Haorui Wu
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