Results 61 to 70 of about 38,518 (253)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Social Network Addiction Scale: The Validity and Reliability Study of Adolescent and Adult Form

International Journal of Assessment Tools in Education, 2019
In this study, it was aimed to develop a validand reliable social network addiction scale for adolescents and young adults.In the Exploratory Factor Analysis of the scale, the application was conductedto 425 high school students between 14-17 years of ...
İbrahim Gökdaş, Yaşar Kuzucu
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Network consumption and sports practice: influence on the risk of network addiction and basic psychological needs

Humanities & Social Sciences Communications
The objective of the study was to identify the possibility of developing a risk of addiction to social networks and to know the satisfaction of basic psychological needs depending on network usage time, the number of networks used, and the practice hours
Marta Vega-Díaz, Higinio González-García   +1 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Network analysis of the relationship between self-injury addiction, attachment, and anxiety in adolescents with non-suicidal self-injury

BMC Psychiatry
Background Non-suicidal self-injury (NSSI) has become increasingly prevalent, with its impact growing more severe among adolescents. Addictive NSSI typically manifests through higher frequencies, more severe injuries, and a broader range of affected body
Lin Zhao, Shijian Wang, Jingya Li, Linghua Kong, Doudou Zheng, Ying Yang   +5 more
doaj   +1 more source

Social Networking Sites Addiction and the Effect of Attitude towards Social Network Advertising

Procedia - Social and Behavioral Sciences, 2016
Abstract Because of the prevalence of mobile devices, the overuse of social networking sites has become a global phenomenon. Social networking sites (hereafter SNS) give a lot of opportunities for business. First of all, businesses can make advertise their product in an easy way.
Can, Lütfiye, Kaya, Nihat
openaire   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source