Results 81 to 90 of about 201,946 (300)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. [PDF]

, 2020
Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia.
Abdellaoui, Abdel, Ames, David, Amunts, Katrin, Andersson, Michael, Armstrong, Nicola J, Bernard, Manon, Blackburn, Nicholas, Blangero, John, Boomsma, Dorret I, Bralten, Janita, Brattbak, Hans-Richard, Brodaty, Henry, Brouwer, Rachel M, Bülow, Robin, Calhoun, Vince, Caspers, Svenja, Cavalleri, Gianpiero, Chen, Chi-Hua, Cichon, Sven, Ciufolini, Simone, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Dale, Anders M, Dalvie, Shareefa, Dazzan, Paola, de Geus, Eco JC, de Zubicaray, Greig I, de Zwarte, Sonja MC, Delanty, Norman, den Braber, Anouk, Desrivières, Sylvane, Doan, Nhat Trung, Donohoe, Gary, Draganski, Bogdan, Ehrlich, Stefan, Espeseth, Thomas, Fisher, Simon E, Franke, Barbara, Frouin, Vincent, Fukunaga, Masaki, Gareau, Thomas, Glahn, David C, Grabe, Hans, Groenewold, Nynke A, Gústafsson, Ómar, Haavik, Jan, Hashimoto, Ryota, Hehir-Kwa, Jayne Y, Heinz, Andreas, Hellard, Stephanie Le, Hibar, Derrek P, Hillegers, Manon HJ, Hoffmann, Per, Holleran, Laurena, Hottenga, Jouke-Jan, Hulshoff, Hilleke E, Håberg, Asta, Ikeda, Masashi, Jahanshad, Neda, Jernigan, Terry, Jockwitz, Christiane, Johansson, Stefan, Jonsdottir, Gudrun A, Jönsson, Erik G, Kahn, Rene, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Knowles, Emma EM, Kolskår, Knut K, Kwok, John B, Leu, Costin, Liu, Jingyu, Lundervold, Arvid, Lundervold, Astri J, Martin, Nicholas G, Martin-Brevet, Sandra, Mather, Karen, Mathias, Samuel R, McCormack, Mark, McMahon, Katie L, McRae, Allan, Milaneschi, Yuri, Moreau, Clara, Morris, Derek, Mothersill, David, Murray, Robin, Mühleisen, Thomas W, Nordvik, Jan E, Nyberg, Lars, Olde Loohuis, Loes M, Ophoff, Roel, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda, Peralta, Juan M, Pike, Bruce, Prieto, Carlos, Sønderby, Ida E   +99 more
core   +1 more source

Autonomy, special offers and routines: a Q methodological study of industry-driven marketing influences on young people's drinking behaviour [PDF]

, 2014
AIM: To identify shared patterns of views in young people relating to the influence of industry-driven alcohol marketing (price, promotion, product and place of purchase/consumption) on their reported drinking behaviour.
Akhtar-Danesh, Anderson, Atkinson, Austin, Babor, Baillie, Baker, Barnes, Beard, Bellis, Bonomo, Borden, Brierley-Jones, Brown, Department for Communities and Local Government (DCLG), Exel, Farrimond, Foxcroft, Gordon, Gore, Goto, Grant, Grier, Hastings, Janssen, Kuntsche, Levy, Lin, Maimaris, McCarthy, McCreanor, Meier, National Institute for Clinical and Health Excellence, Neale, Nicholls, O'Dowd, O'Neil, O'Neil, Rosenquist, Seaman, Siegal, Stenner, Stephenson, Townshend, Watts, Watts, Watts, Windle, Witt, Wood, Zeigler   +50 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Network consumption and sports practice: influence on the risk of network addiction and basic psychological needs

Humanities & Social Sciences Communications
The objective of the study was to identify the possibility of developing a risk of addiction to social networks and to know the satisfaction of basic psychological needs depending on network usage time, the number of networks used, and the practice hours
Marta Vega-Díaz, Higinio González-García   +1 more
doaj   +1 more source

The relationships between mental health and social media addiction, and between academic burnout and social media addiction among Chinese college students: A network analysis

Heliyon
Background: The rapid growth in the use of social media applications on the internet has significant impacts on mental health, especially among university students.
Tingwei Feng, Buyao Wang, Mingdi Mi, Lei Ren, Lin Wu, Hui Wang, Xufeng Liu, Xiuchao Wang   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Network analysis of the relationship between self-injury addiction, attachment, and anxiety in adolescents with non-suicidal self-injury

BMC Psychiatry
Background Non-suicidal self-injury (NSSI) has become increasingly prevalent, with its impact growing more severe among adolescents. Addictive NSSI typically manifests through higher frequencies, more severe injuries, and a broader range of affected body
Lin Zhao, Shijian Wang, Jingya Li, Linghua Kong, Doudou Zheng, Ying Yang   +5 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Symptom-level interactions between digital addiction and psychological resources: a large-scale cross-validation study

Frontiers in Psychology
BackgroundDigital addiction in adolescents is often conceptualized as a latent construct, masking the complex interplay between specific symptoms and psychological resources.
Abdullah Aldemir
doaj   +1 more source