Results 41 to 50 of about 148,159 (258)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

USABILITY AND SECURITY ASPECTS OF SOCIAL NETWORK SITES (SNS) [PDF]

open access: yesICTACT Journal on Communication Technology, 2011
The rising level of Social Network Sites (SNS) is incredible. An SNS is a network system which offers quality services like connecting users and providing a platform to establish communications among the individuals of common interest.
P. Venkateswari, T. Purusothaman
doaj  

Diffusion of responsibility on social networking sites [PDF]

open access: yesComputers in Human Behavior, 2015
Social networking presents opportunities for diffusion of responsibility and so research on prosocial behavior.Participants viewed a mock social networking site embedded with requests for help.We manipulated the number of other people online and the time since the request was made.Offers to help were influenced by the number of 'others' online as well ...
Katie K. Martin, Adrian C. North
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

WHAT'S UP? NOT SO MUCH. NETWORKING AND COMMUNICATING VIA SOCIAL NETWORK SITES [PDF]

open access: yesInnovative Issues and Approaches in Social Sciences, 2018
The article presents the phenomena of social network sites as a modern and important framework for communication and establishing relationships. The article therefore presents some global trends characteristic for modern society. One of the major driving
Tadej Praprotnik
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Impact of online social media on consumers’ purchasing intention via social network sites

open access: yesHo Chi Minh City Open University Journal of Science - Economics and Business Administration, 2018
With the continuous development of the internet and e-commerce in Vietnam recently, there is much research on online purchasing behaviors through retail websites.
Hoang Thi Phuong Thao   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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