Results 101 to 110 of about 753,725 (301)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Social Networking Sites and Our Lives [PDF]
, 2011 Examines the characteristics of social networking site users, their online activities, and their friendships, sense of trust, social support, perspectives, and civic engagement by site and compared with those of non-users and users of other ...
Keith N. Hampton +3 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Transparency in Cooperative Online Education
International Review of Research in Open and Distributed Learning, 2009 The purpose of this article is to discuss the following question: What is the potential of social networking within cooperative online education? Social networking does not necessarily involve communication, dialogue, or collaboration.
Christian Dalsgaard +1 more
doaj +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Journal Riphah College of Rehabilitation Sciences, 2018 Background: This study investigates how physical active students are and what is the effect of social networking on their physical activity.
Shafaq Shahid +3 more
doaj
Use of social networking websites as a care instrument for hospitalized adolescents
Escola Anna Nery, 2017 Objective: This study aimed to understand how social networking websites are used by adolescents and their importance during the hospitalization process.
Camila Amaral Borghi +5 more
doaj +1 more source
AGENT: Alumni growth and engagement across new technologies [PDF]
, 2012 The AGENT project aims to use social networking technologies (LinkedIn and Facebook) to support the development of undergraduates’ employability and career development.
Coughlan, J, Jamal, A, Macredie, RD
core
SocialDTN: A DTN implementation for Digital and Social Inclusion
, 2013 Despite of the importance of access to computers and to the Internet for the development of people and their inclusion in society, there are people that still suffer with digital divide and social exclusion. Delay/Disruption-Tolerant Networking (DTN) can
Cerqueira, Eduardo +4 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source