Results 111 to 120 of about 15,667,104 (396)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Immigration from the Immigrants’ Perspective: Analyzing Survey Data Collected among Immigrants and Host Society Members

Social Inclusion, 2019
Immigration has been one of the most crucial global phenomena, changing the fabric of many societies, and a topic of substantial research. Much of this research has focused on how the host society views immigrants and immigration, or on the societal ...
Alice Ramos, Eldad Davidov, Peter Schmidt, Marta Vilar Rosales, Dina Maskileyson   +4 more
doaj   +1 more source

Detecting Community Structure in Dynamic Social Networks Using the Concept of Leadership

, 2017
Detecting community structure in social networks is a fundamental problem empowering us to identify groups of actors with similar interests. There have been extensive works focusing on finding communities in static networks, however, in reality, due to ...
A Clauset, A Clauset, A Lancichinetti, A Lancichinetti, J Leskovec, J Xie, L Lü, MEJ Newman, N Eagle, P Holme, Q Chen, S Bilke, S Chakrabati, S Fortunato, TW Valente, U Brandes, V Kawadia, VD Blondel, Y-R Lin   +18 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Behavioural patterns in social networks [PDF]

, 2011
In this paper, we focus on the analysis of individual decision making for the formation of social networks, using experimentally generated data. We first analyse the determinants of the individual demand for links under the assumption of agents' static ...
Conte, A., Di Cagno, D., Sciubba, Emanuela   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Taming out-of-equilibrium dynamics on interconnected networks

Nature Communications, 2019
Network properties can be modified when they interact with other networks, yet most previous results have focused on equilibrium states exclusively.
Javier M. Buldú, Federico Pablo-Martí, Jacobo Aguirre   +2 more
doaj   +1 more source

Does the Diabetes Specialist Nursing workforce impact the experiences and outcomes of people with diabetes? A hermeneutic review of the evidence

Human Resources for Health, 2019
Objectives The aim of the hermeneutic review was to identify and clarify the mechanisms by which the Diabetes Specialist Nursing workforce affect the outcomes of diabetes patients, with a focus on those in the United Kingdom.
Jessica Lawler, Paul Trevatt, Clare Elliot, Alison Leary   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Seed selection for information cascade in multilayer networks

, 2017
Information spreading is an interesting field in the domain of online social media. In this work, we are investigating how well different seed selection strategies affect the spreading processes simulated using independent cascade model on eighteen ...
E Omodei, F Erlandsson, J Demšar, M Kitsak, M Salehi, MJ Zaki   +5 more
core   +1 more source