Results 111 to 120 of about 792,044 (341)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Semantic Social Network Analysis [PDF]

open access: yesarXiv, 2009
Social Network Analysis (SNA) tries to understand and exploit the key features of social networks in order to manage their life cycle and predict their evolution. Increasingly popular web 2.0 sites are forming huge social network. Classical methods from social network analysis (SNA) have been applied to such online networks.
arxiv  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Scalable Analysis for Large Social Networks: the data-aware mean-field approach [PDF]

open access: yesarXiv, 2012
Studies on social networks have proved that endogenous and exogenous factors influence dynamics. Two streams of modeling exist on explaining the dynamics of social networks: 1) models predicting links through network properties, and 2) models considering the effects of social attributes.
arxiv  

Dynamics of Social Networks

open access: yesProcedia - Social and Behavioral Sciences, 2011
AbstractIn the past decade Social Network Analysis (SNA) has become an established research field in the social and behavioral sciences as well as the natural sciences. The international conference on Applications of Social Network Analysis (ASNA) brings this interdisciplinary community together to assess the state of the field and discuss current ...
openaire   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Multi-layered Social Networks [PDF]

open access: yesarXiv, 2012
It is quite obvious that in the real world, more than one kind of relationship can exist between two actors and that those ties can be so intertwined that it is impossible to analyse them separately [Fienberg 85], [Minor 83], [Szell 10]. Social networks with more than one type of relation are not a completely new concept [Wasserman 94] but they were ...
arxiv  

Attempted suicide in social networks. [PDF]

open access: bronze, 1969
Norman Kreitman, P Smith, Eng-Seong Tan
openalex   +1 more source

Social networks and the firm

open access: yesRevista de Administração, 2016
Individuals often base their decisions on what they observe in their neighborhood or peer groups. It can be, on the one hand, that individuals gather information from their peers’ experiences: for example, a consumer will be more likely to adopt a given product if many of that consumer’s friends report a positive experience with the product.
Goyal, Sanjeev, Gagnon, Julien
openaire   +4 more sources

Time, the final frontier

open access: yesMolecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain   +3 more
wiley   +1 more source

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