Results 91 to 100 of about 14,746,680 (258)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Social Networks in Labor Markets [PDF]
Research in sociology and economics point to important role for social networks in labor markets. Social contacts mediate propagation of rich and reliable information among indi- viduals and thus help workers find jobs and employers find employees ...
Antoni Calvo-Armengol +1 more
core
Social networks in transnational and virtual communities [PDF]
, 2003 There has been extensive research on social networks but little is known about why some communities survive and some disintegrate. This paper provides a framework to explain similarities in many types of communities.
Sudweeks, F. +3 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Care Networks Project: Growing and Maintaining Social Networks for Older People
, 2010 This report documents the findings of an innovative qualitative research project which investigated the nature of social networks that develop through caring for frail older people.
Leonard, Rosemary (R8047) +3 more
core
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
10041 Executive Summary – Perspectives Workshop: Digital Social Networks [PDF]
, 2010 The Perspective Workshop on “Digital Social Networks” held in between January 25th and 29th, 2010 at the research centre Schloss Dagstuhl focused on technological, socio-economical, and political aspects of digital social networks, and, more generally ...
Schaffert, Sebastian +4 more
core +1 more source
Social Inclusion, 2019 Immigration has been one of the most crucial global phenomena, changing the fabric of many societies, and a topic of substantial research. Much of this research has focused on how the host society views immigrants and immigration, or on the societal ...
Alice Ramos +4 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source