Results 121 to 130 of about 15,435,726 (351)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Social Media Firm Specific Advantages as Enablers of Network Embeddedness of International Entrepreneurial Ventures

, 2020
Sara Fraccastoro, Mika Gabrielsson, Sylvie Chetty   +2 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Spatial Social Networks [PDF]

social networks;implementation;spatial cost ...
Gilles, R.P., Johnson, C.
core   +1 more source

SOCIAL SUPPORT NETWORKS FOR WOMEN IN SITUATIONS OF VIOLENCE BY AN INTIMATE PARTNER [PDF]

, 2017
Leônidas de Albuquerque Netto, Maria Aparecida Vasconcelos Moura, Carla Luzia França Araújo, Maria Helena do Nascimento Souza, Giuliana Fernandes e Silva   +4 more
openalex   +1 more source

The Role of Social Media Networks in Enriching the Arabic Digital Content in Humanities and Sciences from the Perspective of Jordanian Universities’ Students

, 2022
Sawsan Badrakhan, Jamal M. Taha, Talal Haimur   +2 more
openalex   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Influence Maximization for Fixed Heterogeneous Thresholds

Scientific Reports, 2019
Influence Maximization is a NP-hard problem of selecting the optimal set of influencers in a network. Here, we propose two new approaches to influence maximization based on two very different metrics. The first metric, termed Balanced Index (BI), is fast
P. D. Karampourniotis, B. K. Szymanski, G. Korniss   +2 more
doaj   +1 more source

New Consensus Reaching Process with Minimum Adjustment and Feedback Mechanism for Large-Scale Group Decision Making Problems Under Social Trust Networks

, 2023
Wei Yang, Luxiang Zhang
openalex   +1 more source