Results 141 to 150 of about 14,284,258 (303)
Clique communities in social networks
, 2011 Given the large amount of data provided by the Web 2.0, there is a pressing need to obtain new metrics to better understand the network structure; how their communities are organized and the way they evolve over time.
Santos, Jorge M. Azevedo +2 more
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Sameness entices, but novelty enchants in fanfiction online
Humanities & Social Sciences CommunicationsCultural evolution is driven by how we choose what to consume and share with others. A common belief is that the cultural artifacts that succeed are the ones that balance novelty and conventionality.
Elise Jing +3 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A pandemic affair? Digital party conferences in Spain
Frontiers in Political ScienceThe COVID-19 pandemic forced parties to face a critical dilemma between freezing their internal processes indefinitely or adapting themselves to sometimes unexplored online formats. Amongst the most affected activities were party congresses.
Adrià Mompó, Oscar Barberà
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Social enterprise networks and social capital: A case study in Scotland/UK [PDF]
, 2014 The chapter focuses on how social aims and cooperative attitudes have been supported in the shaping of networks in Scotland, and why this is relevant for the sustainable development of social enterprise and communities. From this background, our main aim
Campbell, Colin, Sacchetti, Silvia
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source