Results 81 to 90 of about 514,953 (316)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Taming out-of-equilibrium dynamics on interconnected networks

Nature Communications, 2019
Network properties can be modified when they interact with other networks, yet most previous results have focused on equilibrium states exclusively.
Javier M. Buldú, Federico Pablo-Martí, Jacobo Aguirre   +2 more
doaj   +1 more source

Does the Diabetes Specialist Nursing workforce impact the experiences and outcomes of people with diabetes? A hermeneutic review of the evidence

Human Resources for Health, 2019
Objectives The aim of the hermeneutic review was to identify and clarify the mechanisms by which the Diabetes Specialist Nursing workforce affect the outcomes of diabetes patients, with a focus on those in the United Kingdom.
Jessica Lawler, Paul Trevatt, Clare Elliot, Alison Leary   +3 more
doaj   +1 more source

An integrated bi-objective optimization model accounting for the social acceptance of renewable fuel production networks

, 2023
Tristan Becker, Michael Wolff, Anika Linzenich, Linda Engelmann, Katrin Arning, Martina Ziefle, Grit Walther   +6 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Social Network Sites in Travel and Tourism: Benefits and Limitations [PDF]

, 2020
Jaroslav Kacetl, Blanka Klímová
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Forecasting national CO2 emissions worldwide

Scientific Reports
Urgent climate action, especially carbon emissions reduction, is required to achieve sustainable goals. Therefore, understanding the drivers of and predicting $$\hbox {CO}_2$$ emissions is a compelling matter.
Lorenzo Costantini, Francesco Laio, Manuel Sebastian Mariani, Luca Ridolfi, Carla Sciarra   +4 more
doaj   +1 more source

Risks and Threats of Social Networks Communication

Communications, 2014
This paper focuses on social networks as a source of information and a tool for its sharing. The first part of the paper defines the theoretical background while the second part is devoted to the evaluation of research which was conducted among ...
Jan Zavodny Pospisil, Lucie Sara Zavodna
doaj   +1 more source