Results 141 to 150 of about 55,459 (294)

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

The mediating role of attitudes to aging in the relationship between information overload, cyberchondria, and influenza vaccine hesitancy among Chinese older adults. [PDF]

Front Public Health
Cheng C.
europepmc   +1 more source

The Influence of Information Overload on Decision Difficulty Mediated by Social Media Exhaustion on Generation Z in Jepara

Ravelina Safaul Khusnah, Mohamad Rifqy Roosdhani   +1 more
openalex   +2 more sources

The Effect of Job Overload on Job Burnout: The Mediating Effect of Positive Psychological Capital and Moderating Effect of Social Support and Personality

, 2013
H. Myra Kim, Tae-Yong Yoo
openalex   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Research on the formation mechanism of social media burnout among college students based on the ISM-MICMAC model. [PDF]

Sci Rep
Wen J, Wang H, Chen H.
europepmc   +1 more source

Behavioural mimicry or herd behaviour of Generation Z? Social media interactions in the context of information overload [PDF]

Krzysztof Stepaniuk, George Lăzăroiu, Chrystyna Misiewicz, Verónica Crespo-Pereira   +3 more
openalex   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

A SEM-ANN analysis to examine impact of AI overreliance through a social cognitive lens: the roles of dependency, FOMO, addiction, and anxiety. [PDF]

BMC Psychol
Zhang J, Yao Z, Kang D, Rasiah R, Gao N.
europepmc   +1 more source