Results 41 to 50 of about 55,459 (294)

Pathway linking health information behaviors to mental health condition during the COVID-19 infodemic: A moderated mediation analysis

Frontiers in Public Health, 2022
BackgroundThe COVID-19 outbreak is no longer a pure epidemiological concern but a true digital infodemic. Numerous conflicting information and misinformation occupy online platforms and specifically social media.
Thomas Hongjie Zhang, Jen Sern Tham, Moniza Waheed, Jeong-Nam Kim, Jae-Seon Jeong, Peng Kee Chang, Abdul Mua'ti@Zamri Ahmad   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Perceived Information Overload and Unverified Information Sharing on WeChat Amid the COVID-19 Pandemic: A Moderated Mediation Model of Anxiety and Perceived Herd

Frontiers in Psychology, 2022
Individuals’ unverified information sharing on social media, namely, sharing information without verification, is a major cause of the widespread misinformation amid the COVID-19 pandemic.
Qing Huang, Sihan Lei, Binbin Ni, Binbin Ni   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The impact of information overload on the information avoidance of medical staff: The moderating and mediating roles of job performance and time pressure

Computers in Human Behavior Reports
This study aims to explore whether social media information overload affects medical staff's information avoidance behavior and the extent to which time pressure mediates and job performance moderates this relationship.
Chun Xia, Jia Xu, Jiaxing Cheng, Yongmei Hou   +3 more
doaj   +1 more source

STUDENT OVERLOAD WITH HOMEWORK IN SOCIAL, ENVIRONMENTAL AND SCIENTIFIC EDUCATION

Facta Universitatis, Series: Teaching, Learning and Teacher Education
The aim of this paper is to present research findings on the effectiveness of homework assignments for primary classroom education students, with a particular focus on Social, Environmental and Scientific Education. It seeks to highlight various aspects of this issue and encourage further discussion and research.
Marija Dejković
openalex   +2 more sources

Work overload and addictive social media use [PDF]

, 2022
Work overload is highly related to mental health issues. Online social media are often used to escape the feelings of overload. In the current study, 291 employees from various job sectors completed an online survey related to work overload, addictive social media use (SMU), and mental health (i.e., depression symptoms, life satisfaction).
Brailovskaia, Julia (PD Dr.), Frahsek, Marc (M. Sc.), Margraf, Jürgen (Prof. Dr.)   +2 more
openaire  

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

The bright side of social media information overload for anti-COVID-19 behaviors: a stimulus-organism-response framework

Frontiers in Public Health
Social media has an important impact on social management by communicating information that influences individual behavior; however, too much social media information can cause user information overload.
Shang Meng, Lingling Zhong, Junwei Cao
doaj   +1 more source