Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Perspectives of social dialogue in the agricultural sector: a cross- and multi-level analysis
Italian Labour Law e-JournalThe article aims to collect and analyze the most recent forms of expression of social dialogue at the European and Italian levels in the agricultural sector.
Ilaria Purificato
doaj +1 more source
The smell of hunger: Norway rats provision social partners based on odour cues of need. [PDF]
PLoS Biol, 2020 Schneeberger K, Röder G, Taborsky M.
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
California Partners for Advanced Transit and Highways Program
The California Partners for Advanced Transit and Highways Program (PATH) has been leading the way in ITS (Intelligent Transportation Systems) research since PATH\u2019s founding in 1986, before the term ITS or its predecessor IVHS (Intelligent Vehicle ...
Partners for Advanced Transit and Highways (Calif.)
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Appendix Q, 2018 natural resources survey report: Bakken Missouri River Crossing Project
, 2019 APPENDIX Q 2018 NATURAL RESOURCES SURVEY REPORT BAKKEN MISSOURI RIVER CROSSING PROJECT Hiland Partners Holdings LLC 2 North Nevada Ave Colorado Springs, CO 80903 January 2019 1032 Seventh Street West, Suite 150 | Saint Paul, MN 55102 | mnrinc.us | 612 ...
Hiland Partners Holdings LLC
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Inaugural meeting on 30th January 2003 of the NAPS social inclusion forum: conference report [PDF]
, 2003 Following an extensive review and consultation process, the Government in early 2002 published its revised National Anti-Poverty Strategy (NAPS) document, entitled "Building an Inclusive Society". This provides a new framework for tackling poverty and
National Economic and Social Forum
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Cloacal bacterial communities of tree swallows (Tachycineta bicolor): Similarity within a population, but not between pair-bonded social partners. [PDF]
PLoS One, 2020 Hernandez J +6 more
europepmc +1 more source