Results 81 to 90 of about 1,688,073 (307)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
New Muslim Cool: Engaging Stakeholders in the Filmmaking Process [PDF]
, 2010 Provides an overview of the production, funding model, project partners, and impact of New Muslim Cool, a documentary film on American Muslim youth culture with a mission to promote interfaith dialogue.
Nina Keim
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Labour Market and Social Policy. CEPS Policy Priorities for 2019-2024, 4 October 2019 [PDF]
, 2019 The mega-trends of digitalisation and automation have already changed labour markets and value chains around the world, with their inevitable economic and social consequences.
Akgüç, Mehtap +3 more
core
Power and politics in research design and practice: Opening up space for social equity in interdisciplinary, multi-jurisdictional and community-based research [PDF]
, 2017 Working collaboratively with communities is commonly considered a cornerstone of good practice in research involving social-ecological concerns. Increasingly, funding agencies also recognise that such collaborations are most productive when community ...
Gagnon, Valoree +2 more
core +4 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Planning-Based Social Partners for Children with Autism
Proceedings of the International Conference on Automated Planning and Scheduling, 2013 This paper describes the design and implementation of a planning-based socially intelligent agent built to help young children with Autism Spectrum Conditions acquire social communication skills. We explain how planning technology allowed us to satisfy the requirements relating to the agent's design that we identified through our ...
Bernardini S, Porayska-Pomsta K
openaire +3 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source