Results 31 to 40 of about 1,248,042 (313)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

A New Model of Care: Community Appointment Day Outcomes and Impact on Musculoskeletal Physiotherapy Waiting Times

Journal of Primary Care & Community Health
Introduction: This study aimed to test the introduction of Community Appointment Days (CADs) for patients on the Musculoskeletal (MSK) Physiotherapy waiting list in Lanarkshire, UK. Methods: A multi-professional team developed, implemented, and evaluated
Helen Alexander, Alan Sinclair, Laura Dover, Brian Slattery, Ruth Currie, Mark Russell, Judith Cain   +6 more
doaj   +1 more source

Well-Aware’ QI Project: Well-Being Support Awareness for Specialty Resident Doctors in Kent

BJPsych Open
Aims: Doctors in training can be at high pressure to balance the service needs with their own training needs, thus leading to a risk of burnout. Hence, supporting their wellbeing is of paramount importance to optimize their training experience.
Suresh Thapaliya, Adeola Adeyemi, Eric Barratt, Rachel Daly   +3 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Improving On-Call Support for Doctors: A Quality Improvement Project

BJPsych Open
Aims Doctors completing on-call shifts at sites across a mental health trust identified a need to improve aspects of on-call work. This quality improvement project (QIP) aimed to improve response to trainee concerns arising from on-call work and support
Sharna Bennett, Verity Williams, James Anslow, Mohan Bhat   +3 more
doaj   +1 more source

Advancing services for adult ADHD: the development of the ADHD Star as a framework for multidisciplinary interventions

BMC Health Services Research, 2016
Background Attention Deficit Hyperactivity Disorder is prevalent in adulthood, resulting in serious impairment across multiple domains of living. Despite clinical guidance recommendations, the relative infancy of research on service provision for adults ...
Marios Adamou, Katharine Graham, Joy MacKeith, Sara Burns, Lisa-Marie Emerson   +4 more
doaj   +1 more source

How integration of dementia services is improving timely dementia diagnosis: an example from Kent. The author wants to share a programme of work from Kent U.K , where system-wide transformation of services has enabled improved time to diagnosis

European Psychiatry, 2023
Introduction The author wants to share a programme of work from Kent, a County in the south-east of England, where integration of services has enabled system wide quality improvement and innovation to achieve improved time to diagnosis, by best use of ...
A. Qazi
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Re-Introducing the Maintenance Slot in the Maidstone KMPT ECT Suite and Enhancing the ECT Clinic’s Capacity by 20%

BJPsych Open
Aims: Kent and Medway NHS and Social Care Partnership Trust (KMPT) had been providing fewer Electroconvulsive Therapy (ECT) treatments per capita compared with the national average.
Maria Moisan, Stanimira Gogova, Chiara Rubino, Brett Metelerkamp   +3 more
doaj   +1 more source

Reconstructing and Mapping Ancestral Land Tenure by the Example of the Starodub Rurikids

Историко-географический журнал, 2023
The article analyzes the general tendencies and peculiarities of the evolution of the Starodub Rurikids family landownership. The specifics of the evolution of the princely family landownership in Starodub uyezd consisted in minimal influence of the ...
A. L. Gryaznov, A. V. Sergeev
doaj   +1 more source