Results 141 to 150 of about 8,899,593 (382)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
The Case for Parental Licensure [PDF]
, 1998 The violent crime-rate in the United States increased nearly 500% from 1960 to 1992. Subsequent small decreases can be attributed to the 500% increase since 1980 in the number of men locked up in American prisons.
Lykken, David T.
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The Pathology of Social Capital in Iran Universities: A Case Study from Sistan and Baluchestan and Zahedan Azad University [PDF]
, 2014 Alireza Sargolzaie
openalex +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Contribution of lipophilicity to the clinical effects of drugs
Российский кардиологический журналThe article is devoted to a detailed analysis of the action of various drugs used in the treatment of hypertension and atherogenic dyslipidemia, depending on their ability to dissolve in fatty media (lipophilicity). The authors analyze connection between
A. S. Skotnikov +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Extending Honneth’s Shift in Focus for Critical Theory [PDF]
, 2016 Axel Honneth has called for a change of focus in Critical Theory "from the self-generated independence of systems to the damage and distortion of social relations of recognition." I argue that Honneth does not shift his methodological focus ...
Giles, Douglas
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