Results 121 to 130 of about 296,086 (336)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Capitalism and Social Pathology [PDF]
Kapitalizm ve Toplumsal Patoloji adlı bu çalışma, kapitalizm ve toplumsal patoloji arasındaki ilişkiyi ele almaktadır. Kapitalizmin toplumsal yapıyı ve bireylerin yaşamlarını nasıl dönüştürdüğünü, salt bir ekonomik sistem olmaktan öte, bireylerin ...
Kara, Zülküf +1 more
core
Pathology of the Implementation System of Iran\'s Social Welfare Policies
فصلنامه رفاه اجتماعی, 2023 Introduction: In the implementation of public policy, there are many factors and obstacles, the identification of which will lead to the efficient way of implementing the policies.
golzar aghaei +2 more
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
#InSituPathologists: how the #USCAP2015 meeting went viral on Twitter and founded the social media movement for the United States and Canadian Academy of Pathology [PDF]
, 2017 David Cohen +23 more
openalex +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The use of wearable technology to measure and support abilities, disabilities and functional skills in autistic youth: a scoping review [PDF]
Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2020 Melissa H. Black +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The restriction of the possible as a social pathology [PDF]
El presente artículo pretende esbozar el concepto de una forma de patología de la vida social que afecta fundamentalmente al ámbito de decisión política.
Romero Cuevas, José Manuel
core +1 more source