Results 101 to 110 of about 296,086 (336)

Ethnolinguistic identity and social cognition: Language prejudice as hermeneutic pathology

open access: yesSign Systems Studies, 2007
Analysts studying the nexus between language and ethnic identity have characterized ethnolinguistic ideologies as the deep structure of overt language practices.
David Herman
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Pathology Case Study: Fever, Purpura and Hypotension [PDF]

open access: yes, 1996
The Department of Pathology at the University of Pittsburgh Medical Center has compiled a wide range of pathology case studies to aid students and instructors in the medical/health science field.
Aronica, Patricia   +3 more
core  

On the ontology of social pathologies [PDF]

open access: yes, 2019
The recent years have seen a rehabilitation of the concept of social pathology in the critical social theory. However, several pertinent questions about how to understand social pathologies remain.
Hirvonen, Onni
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Pathology [PDF]

open access: yes, 1983
The Deficit Model of pathology is presented in contrast to the traditional Medical Model and Behavioral Model. The structure of the Deficit Model as a Descriptive-Psychology formulation is given in some detail.
Ossorio, Peter G.
core   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Critical Theory and Social Pathology [PDF]

open access: yes, 2018
This Chapter presents an analysis of the idea of social pathology and its role in Frankfurt School Critical Theory. I suggest that this idea can set Critical Theory apart from mainstream liberal approaches, but also note the challenges involved in doing ...
Freyenhagen, Fabian
core  

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