Results 101 to 110 of about 293,038 (290)

Humanitarian competencies of a doctor (cardiologist)

open access: yesРоссийский кардиологический журнал, 2019
The article reveals the features of working with the patient as a social and psychological subject, who, in addition to somatic pathology, has an experience of the disease situation.
E. O. Taratukhin
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Strategies for building pathology reports in an urban rehabilitation process: Project of the Old City Centre of Coimbra

open access: yes, 2005
The increasing interest on architectural heritage associated to the recognised building value, at economic, social and cultural levels have stimulated, in the recent decades, the urban rehabilitation and renovation o several cities in Europe.
Silva, J. A. R. Mendes da   +2 more
core  

Non-Suicidal Self-Injury and Indirect Self-Harm Among Danish High School Students [PDF]

open access: yesScandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2014
Bo Møhl, Peter la Cour, Annika Skandsen
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Flattery Harm in Social Interactions and its Pathology from Imam Ali’s Viewpoint

open access: yesپژوهش در دین و سلامت, 2019
For downloading the full-text of this article please click here. Background and Objective: The issue of flattery and its individual and social consequences are regarded as a moral vice in many human societies and the higher degree of this trait in the ...
Omid Ebrahimi   +2 more
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Facilitating participation of children with disability and commuication difficulties in leisure : parents' perceptions and experiences

open access: yes, 2018
Background: Participation is a multidimensional experience influenced by personal, interpersonal, socio-cultural and environmental factors. Currently, relatively little literature exists that explores the roles and experiences of parents as they ...
Edwards, Ann   +2 more
core  

Pathology & Social Media

open access: yes, 2022
This dissertation entitled “Pathology and Social Media” examines the effects of social media on young minds. In the thesis, I have tried to ascertain whether there is a causal link between the uses of social media and the development of pathological ...
Korgaard, Freja Præst
core  

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