Mechanism of selective lesion of the cardiovascular system in psycho-emotional stress [PDF]
A species predisposition to hypertensive and ischemic heart disease occurs in mammals only at the level of primates, and is associated with social regulation of biological reactions.
Repin, Y. M., Startsev, V. G.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Mourning and its Cultural-Social Pathology in Iran [PDF]
اسلام و مطالعات اجتماعی, 2016 Mourning, due to its personal and social constructive role, has a special status in the Islam school and the biography of the Prophet’s Household. However, this fertile ritual, like any fruitful practice, doesn't have its desired results if it doesn't ...
Seyfollah Qanbari nik, Hakime Ehsani
doaj
The Mediating Effect of Specific Social Anxiety Facets on Body Checking and Avoidance
Frontiers in Psychology, 2019 Objective: Body checking (BC) and avoidance (BA) form the behavioral component of body image disturbance. High levels of BC/BA have often been documented to hold a positive and potentially reinforcing relationship with eating pathology.
Anne Kathrin Radix +3 more
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Emergence of nonmotor symptoms as the focus of research and treatment of Parkinson's disease: Introduction to the special section on nonmotor dysfunctions in Parkinson's disease [PDF]
, 2013 Parkinson's disease (PD) is traditionally characterized by the cardinal motor symptoms of tremor, rigidity, slowness of movement, and impairments of posture, gait, and balance.
Cronin-Golomb, Alice
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Burnout as a social pathology in nursing professionals: an analysis based on the theory of recognition. [PDF]
Rev Bras Med Trab, 2022 Garcia JC.
europepmc +1 more source
Effect of front and back squat techniques on peak loads experienced by the Achilles tendon [PDF]
, 2015 Background A primary technique in the discipline of strength and conditioning the squat has two principal ‘back and front’ variants. Despite the physiological and strength benefits of the squat, the propensity for musculoskeletal injury is high.
Atkins, Stephen +4 more
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