Results 81 to 90 of about 296,086 (336)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Strategies for building pathology reports in an urban rehabilitation process: Project of the Old City Centre of Coimbra [PDF]
, 2005 The increasing interest on architectural heritage associated to the recognised building value, at economic, social and cultural levels have stimulated, in the recent decades, the urban rehabilitation and renovation o several cities in Europe.
Silva, J. A. R. Mendes da +2 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Facilitating participation of children with disability and commuication difficulties in leisure : parents' perceptions and experiences [PDF]
, 2018 Background: Participation is a multidimensional experience influenced by personal, interpersonal, socio-cultural and environmental factors. Currently, relatively little literature exists that explores the roles and experiences of parents as they ...
Edwards, Ann +2 more
core
Pathology & Social Media [PDF]
, 2022 This dissertation entitled “Pathology and Social Media” examines the effects of social media on young minds. In the thesis, I have tried to ascertain whether there is a causal link between the uses of social media and the development of pathological ...
Korgaard, Freja Præst
core
Mourning and its Cultural-Social Pathology in Iran [PDF]
اسلام و مطالعات اجتماعی, 2016 Mourning, due to its personal and social constructive role, has a special status in the Islam school and the biography of the Prophet’s Household. However, this fertile ritual, like any fruitful practice, doesn't have its desired results if it doesn't ...
Seyfollah Qanbari nik, Hakime Ehsani
doaj
The Mediating Effect of Specific Social Anxiety Facets on Body Checking and Avoidance
Frontiers in Psychology, 2019 Objective: Body checking (BC) and avoidance (BA) form the behavioral component of body image disturbance. High levels of BC/BA have often been documented to hold a positive and potentially reinforcing relationship with eating pathology.
Anne Kathrin Radix +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source