Results 61 to 70 of about 11,831,585 (290)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Incentivised chronic disease management and the inverse equity hypothesis: findings from a longitudinal analysis of Scottish primary care practice-level data

BMC Medicine, 2017
Background The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK’s pay-for-performance scheme for chronic disease management (CDM) in primary care general ...
Richard Lowrie, Alex McConnachie, Andrea E. Williamson, Evangelos Kontopantelis, Marie Forrest, Norman Lannigan, Stewart W. Mercer, Frances S. Mair   +7 more
doaj   +1 more source

Social prescribing practices and learning across the North West Coast region: essential elements and key challenges to implementing effective and sustainable social prescribing services

BMC Health Services Research, 2023
Introduction Social prescribing has become an important feature of the UK primary care offer. However, there remains limited evidence on how best to implement and deliver social prescribing programmes to maximise effectiveness and long-term ...
Shaima M. Hassan, Adele Ring, Mark Goodall, Katharine Abba, Mark Gabbay, Nadja van Ginneken   +5 more
doaj   +1 more source

Supporting Vulnerable Populations During the Pandemic: Stakeholders’ Experiences and Perceptions of Social Prescribing in Scotland During Covid-19 [PDF]

, 2022
Social prescribing schemes refer people toward personalized health/wellbeing interventions in local communities. Since schemes hold different representations of social prescribing, responses to the pandemic crisis will vary. Intersectionality states that
Fixsen, Alison, Barrett, Simon, Simonovich, Michal, Barrett, S., Shimonovich, M.   +4 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Enhancing student wellbeing through nature-based social prescribing: A social return on investment evaluation

Wellbeing, Space and Society
Background: Social prescribing (SP) is a non-clinical approach connecting citizens to community support to better manage their health and wellbeing. Wrexham University (WU) offers a Nature-based Social Prescribing (NBSP) pathway for students to connect ...
Abraham Makanjuola, Carolyn A. Wallace, Mary Lynch   +2 more
doaj   +1 more source

Establishing internationally accepted conceptual and operational definitions of social prescribing through expert consensus: a Delphi study

BMJ Open, 2023
Objective The aim of this study was to establish internationally accepted conceptual and operational definitions of social prescribing.Design A three-round Delphi study was conducted.Setting This study was conducted virtually using an online survey ...
Imaan Bayoumi, Rachelle Ashcroft, Christina Godfrey, Kate Mulligan, Caitlin Muhl   +4 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

An audit of Supplementary Prescribing within South West Yorkshire Mental Health Trust [PDF]

, 2008
Results are presented from an audit of mental health nurses (MHNs) who have undertaken training in order to practise as supplementary prescribers as part of an evaluation of the development of non-medical prescribing (NMP) across South West Yorkshire ...
Hemingway, Steve, Baxter, Hazel, Clibbens, Richard   +2 more
core   +1 more source